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Molecular Evidence of Malaria and Zoonotic Diseases Among Rapid Diagnostic Test-Negative Febrile Patients in Low-Transmission Season, Mali

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@article{063e467c98124cf79262d03c3ce0bd0f,
title = "Molecular Evidence of Malaria and Zoonotic Diseases Among Rapid Diagnostic Test-Negative Febrile Patients in Low-Transmission Season, Mali",
abstract = "From November to December 2012 in S{\'e}lingu{\'e}-Mali, blood samples from 88 febrile patients who tested negative by malaria Paracheck{\circledR}rapid diagnostic tests (RDTs) were used to assess the presence of sub-RDTPlasmodium falciparumas well asBorrelia,Coxiella burnetii, andBabesiaapplying molecular tools.Plasmodiumsp. was present among 57 (60.2{\%}) of the 88 malaria RDT-negative patients, whereas the prevalence ofBorrelia,C. burnetii, andBabesiawere 3.4{\%} (N= 3), 1.1{\%} (N= 1), and 0.0{\%}, respectively. The additional diagnostic use of polymerase chain reaction (PCR) identified a high proportion ofPlasmodiumsp.-positive samples and although this may be a concern for malaria control, the respective PCR-identified malaria infections were less likely responsible for the observed fevers given the low parasite density. Also, the low infection levels ofBorreliaandC. burnetiiand lack ofBabesiaamong the febrile patients call for further studies to assess the causes of fever among malaria RDT-negative patients in S{\'e}lingu{\'e}.",
keywords = "Adolescent, Adult, Animals, Babesiosis, Borrelia Infections, Child, Child, Preschool, False Negative Reactions, Female, Fever, Humans, Malaria, Falciparum, Male, Mali, Middle Aged, Polymerase Chain Reaction, Q Fever, Seasons, Young Adult, Zoonoses, Journal Article",
author = "Mahamoudou Tour{\'e} and Petersen, {Pelle T} and Bathily, {Sidy N'd} and Daouda Sanogo and Wang, {Christian W} and Schi{\o}ler, {Karin L} and Flemming Konradsen and Seydou Doumbia and Michael Alifrangis",
note = "{\circledC} The American Society of Tropical Medicine and Hygiene.",
year = "2017",
month = "2",
day = "8",
doi = "10.4269/ajtmh.16-0700",
language = "English",
volume = "96",
pages = "335--337",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "2",

}

RIS

TY - JOUR

T1 - Molecular Evidence of Malaria and Zoonotic Diseases Among Rapid Diagnostic Test-Negative Febrile Patients in Low-Transmission Season, Mali

AU - Touré, Mahamoudou

AU - Petersen, Pelle T

AU - Bathily, Sidy N'd

AU - Sanogo, Daouda

AU - Wang, Christian W

AU - Schiøler, Karin L

AU - Konradsen, Flemming

AU - Doumbia, Seydou

AU - Alifrangis, Michael

N1 - © The American Society of Tropical Medicine and Hygiene.

PY - 2017/2/8

Y1 - 2017/2/8

N2 - From November to December 2012 in Sélingué-Mali, blood samples from 88 febrile patients who tested negative by malaria Paracheck®rapid diagnostic tests (RDTs) were used to assess the presence of sub-RDTPlasmodium falciparumas well asBorrelia,Coxiella burnetii, andBabesiaapplying molecular tools.Plasmodiumsp. was present among 57 (60.2%) of the 88 malaria RDT-negative patients, whereas the prevalence ofBorrelia,C. burnetii, andBabesiawere 3.4% (N= 3), 1.1% (N= 1), and 0.0%, respectively. The additional diagnostic use of polymerase chain reaction (PCR) identified a high proportion ofPlasmodiumsp.-positive samples and although this may be a concern for malaria control, the respective PCR-identified malaria infections were less likely responsible for the observed fevers given the low parasite density. Also, the low infection levels ofBorreliaandC. burnetiiand lack ofBabesiaamong the febrile patients call for further studies to assess the causes of fever among malaria RDT-negative patients in Sélingué.

AB - From November to December 2012 in Sélingué-Mali, blood samples from 88 febrile patients who tested negative by malaria Paracheck®rapid diagnostic tests (RDTs) were used to assess the presence of sub-RDTPlasmodium falciparumas well asBorrelia,Coxiella burnetii, andBabesiaapplying molecular tools.Plasmodiumsp. was present among 57 (60.2%) of the 88 malaria RDT-negative patients, whereas the prevalence ofBorrelia,C. burnetii, andBabesiawere 3.4% (N= 3), 1.1% (N= 1), and 0.0%, respectively. The additional diagnostic use of polymerase chain reaction (PCR) identified a high proportion ofPlasmodiumsp.-positive samples and although this may be a concern for malaria control, the respective PCR-identified malaria infections were less likely responsible for the observed fevers given the low parasite density. Also, the low infection levels ofBorreliaandC. burnetiiand lack ofBabesiaamong the febrile patients call for further studies to assess the causes of fever among malaria RDT-negative patients in Sélingué.

KW - Adolescent

KW - Adult

KW - Animals

KW - Babesiosis

KW - Borrelia Infections

KW - Child

KW - Child, Preschool

KW - False Negative Reactions

KW - Female

KW - Fever

KW - Humans

KW - Malaria, Falciparum

KW - Male

KW - Mali

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Q Fever

KW - Seasons

KW - Young Adult

KW - Zoonoses

KW - Journal Article

U2 - 10.4269/ajtmh.16-0700

DO - 10.4269/ajtmh.16-0700

M3 - Journal article

VL - 96

SP - 335

EP - 337

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 2

ER -

ID: 52821869