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Molecular basis of antifungal drug resistance in yeasts

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Morio, Florent ; Jensen, Rasmus Hare ; Le Pape, Patrice ; Arendrup, Maiken Cavling. / Molecular basis of antifungal drug resistance in yeasts. I: International Journal of Antimicrobial Agents. 2017 ; Bind 50, Nr. 5. s. 599-606.

Bibtex

@article{5c5ed2a00e4742b7bcf64d48643d109e,
title = "Molecular basis of antifungal drug resistance in yeasts",
abstract = "Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.",
keywords = "Journal Article",
author = "Florent Morio and Jensen, {Rasmus Hare} and {Le Pape}, Patrice and Arendrup, {Maiken Cavling}",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.",
year = "2017",
month = nov,
doi = "10.1016/j.ijantimicag.2017.05.012",
language = "English",
volume = "50",
pages = "599--606",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier BV",
number = "5",

}

RIS

TY - JOUR

T1 - Molecular basis of antifungal drug resistance in yeasts

AU - Morio, Florent

AU - Jensen, Rasmus Hare

AU - Le Pape, Patrice

AU - Arendrup, Maiken Cavling

N1 - Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

PY - 2017/11

Y1 - 2017/11

N2 - Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.

AB - Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.

KW - Journal Article

U2 - 10.1016/j.ijantimicag.2017.05.012

DO - 10.1016/j.ijantimicag.2017.05.012

M3 - Journal article

C2 - 28669835

VL - 50

SP - 599

EP - 606

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 5

ER -

ID: 52080852