Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Molecular basis of antifungal drug resistance in yeasts

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genetic characterization confirms sporadic occurrence of vancomycin-resistant Enterococcus faecalis in Copenhagen, Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hyperbaric oxygen therapy augments tobramycin efficacy in experimental Staphylococcus aureus endocarditis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antimicrobial resistance in the Bacteroides fragilis group in faecal microbiota from healthy Danish children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. EUCAST Reference Testing of Rezafungin Susceptibility and Impact of Choice of Plastic Plates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.

OriginalsprogEngelsk
TidsskriftInternational Journal of Antimicrobial Agents
Vol/bind50
Udgave nummer5
Sider (fra-til)599-606
Antal sider8
ISSN0924-8579
DOI
StatusUdgivet - nov. 2017

ID: 52080852