Molecular basis of antifungal drug resistance in yeasts

Florent Morio, Rasmus Hare Jensen, Patrice Le Pape, Maiken Cavling Arendrup

71 Citationer (Scopus)

Abstract

Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.

OriginalsprogEngelsk
TidsskriftInternational Journal of Antimicrobial Agents
Vol/bind50
Udgave nummer5
Sider (fra-til)599-606
Antal sider8
ISSN0924-8579
DOI
StatusUdgivet - nov. 2017

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