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Model for end-stage liver disease score predicts complications after liver transplantation

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@article{1e8304e1c2624c268df11b6b7e225819,
title = "Model for end-stage liver disease score predicts complications after liver transplantation",
abstract = "PURPOSE: Increased model for end-stage liver disease (MELD) score measured in the early postoperative course is associated with one-year mortality and graft loss. However, the correlation with postoperative complications has not been investigated. The aim of this study was to investigate the association between postoperative MELD score and subsequent complications.METHODS: Adult liver transplant recipients transplanted from January 2011 until December 2016 were included. MELD score days 1-5 were correlated with complications day 6-30, subdivided into type and severity according to Clavien-Dindo classification.RESULTS: We included 246 adult liver transplant recipients. Between days 6 and 30, 671 complications occurred in 201 of the patients (82%) corresponding to 64% of all postoperative complications in the whole postoperative period (days 0-30). In multivariate analyses adjusted for recipient gender and age, preoperative MELD score, and Eurotransplant Donor Risk Index, postoperative MELD score was significantly associated with having one or more complications, any type of complication except cardiovascular and renal complications, and complication severity.CONCLUSIONS: Postoperative MELD score days 1-5 were associated with complications arising in the subsequent period 6-30 days after transplantation. An increased MELD score should heighten the clinician's awareness of a possible complication.",
keywords = "Liver transplantation, Postoperative, Posttransplant, MELD score, Model for end-stage liver disease, Complications, Clavien-Dindo",
author = "Hans-Christian Pommergaard and Daugaard, {Thomas R{\o}jkj{\ae}r} and Rostved, {Andreas Arendtsen} and Schultz, {Nicolai Aagaard} and Jens Hillings{\o} and Krohn, {Paul Suno} and Allan Rasmussen",
year = "2021",
month = feb,
doi = "10.1007/s00423-020-02018-3",
language = "English",
volume = "406",
pages = "55--65",
journal = "Langenbecks Archives of Surgery",
issn = "1435-2443",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Model for end-stage liver disease score predicts complications after liver transplantation

AU - Pommergaard, Hans-Christian

AU - Daugaard, Thomas Røjkjær

AU - Rostved, Andreas Arendtsen

AU - Schultz, Nicolai Aagaard

AU - Hillingsø, Jens

AU - Krohn, Paul Suno

AU - Rasmussen, Allan

PY - 2021/2

Y1 - 2021/2

N2 - PURPOSE: Increased model for end-stage liver disease (MELD) score measured in the early postoperative course is associated with one-year mortality and graft loss. However, the correlation with postoperative complications has not been investigated. The aim of this study was to investigate the association between postoperative MELD score and subsequent complications.METHODS: Adult liver transplant recipients transplanted from January 2011 until December 2016 were included. MELD score days 1-5 were correlated with complications day 6-30, subdivided into type and severity according to Clavien-Dindo classification.RESULTS: We included 246 adult liver transplant recipients. Between days 6 and 30, 671 complications occurred in 201 of the patients (82%) corresponding to 64% of all postoperative complications in the whole postoperative period (days 0-30). In multivariate analyses adjusted for recipient gender and age, preoperative MELD score, and Eurotransplant Donor Risk Index, postoperative MELD score was significantly associated with having one or more complications, any type of complication except cardiovascular and renal complications, and complication severity.CONCLUSIONS: Postoperative MELD score days 1-5 were associated with complications arising in the subsequent period 6-30 days after transplantation. An increased MELD score should heighten the clinician's awareness of a possible complication.

AB - PURPOSE: Increased model for end-stage liver disease (MELD) score measured in the early postoperative course is associated with one-year mortality and graft loss. However, the correlation with postoperative complications has not been investigated. The aim of this study was to investigate the association between postoperative MELD score and subsequent complications.METHODS: Adult liver transplant recipients transplanted from January 2011 until December 2016 were included. MELD score days 1-5 were correlated with complications day 6-30, subdivided into type and severity according to Clavien-Dindo classification.RESULTS: We included 246 adult liver transplant recipients. Between days 6 and 30, 671 complications occurred in 201 of the patients (82%) corresponding to 64% of all postoperative complications in the whole postoperative period (days 0-30). In multivariate analyses adjusted for recipient gender and age, preoperative MELD score, and Eurotransplant Donor Risk Index, postoperative MELD score was significantly associated with having one or more complications, any type of complication except cardiovascular and renal complications, and complication severity.CONCLUSIONS: Postoperative MELD score days 1-5 were associated with complications arising in the subsequent period 6-30 days after transplantation. An increased MELD score should heighten the clinician's awareness of a possible complication.

KW - Liver transplantation

KW - Postoperative

KW - Posttransplant

KW - MELD score

KW - Model for end-stage liver disease

KW - Complications

KW - Clavien-Dindo

U2 - 10.1007/s00423-020-02018-3

DO - 10.1007/s00423-020-02018-3

M3 - Journal article

C2 - 33140185

VL - 406

SP - 55

EP - 65

JO - Langenbecks Archives of Surgery

JF - Langenbecks Archives of Surgery

SN - 1435-2443

IS - 1

ER -

ID: 61892565