TY - JOUR
T1 - MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay
AU - Veidal, Sanne Skovgård
AU - Karsdal, Morten Asser
AU - Vassiliadis, Efstathios
AU - Nawrocki, Arkadiusz
AU - Larsen, Martin Røssel
AU - Nguyen, Quoc Hai Trieu
AU - Hägglund, Per
AU - Luo, Yunyun
AU - Zheng, Qinlong
AU - Vainer, Ben
AU - Leeming, Diana Julie
PY - 2011
Y1 - 2011
N2 - During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis.
AB - During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis.
U2 - 10.1371/journal.pone.0024753
DO - 10.1371/journal.pone.0024753
M3 - Journal article
C2 - 21935455
SN - 1932-6203
VL - 6
SP - e24753
JO - P L o S One
JF - P L o S One
IS - 9
ER -