Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  • Vassili Panagides
  • David Del Val
  • Mohamed Abdel-Wahab
  • Norman Mangner
  • Eric Durand
  • Nikolaj Ihlemann
  • Marina Urena
  • Costanza Pellegrini
  • Francesco Giannini
  • Piotr Scislo
  • Zenon Huczek
  • Martin Landt
  • Vincent Auffret
  • Jan Malte Sinning
  • Asim N Cheema
  • Luis Nombela-Franco
  • Chekrallah Chamandi
  • Francisco Campelo-Parada
  • Erika Munoz-Garcia
  • Howard C Herrmann
  • Luca Testa
  • Won-Keun Kim
  • Juan Carlos Castillo
  • Alberto Alperi
  • Didier Tchetche
  • Antonio L Bartorelli
  • Samir Kapadia
  • Stefan Stortecky
  • Ignacio Amat-Santos
  • Harindra C Wijeysundera
  • John Lisko
  • Enrique Gutiérrez-Ibanes
  • Vicenç Serra
  • Luisa Salido
  • Abdullah Alkhodair
  • Ugolino Livi
  • Tarun Chakravarty
  • Stamatios Lerakis
  • Victoria Vilalta
  • Ander Regueiro
  • Rafael Romaguera
  • Utz Kappert
  • Marco Barbanti
  • Jean-Bernard Masson
  • Frédéric Maes
  • Claudia Fiorina
  • Antonio Miceli
  • Susheel Kodali
  • Henrique B Ribeiro
  • Jose Armando Mangione
  • Fabio Sandoli de Brito
  • Guglielmo Mario Actis Dato
  • Francesco Rosato
  • Maria-Cristina Ferreira
  • Valter Correia de Lima
  • Alexandre Siciliano Colafranceschi
  • Alexandre Abizaid
  • Marcos Antonio Marino
  • Vinicius Esteves
  • Julio Andrea
  • Roger R Godinho
  • Fernando Alfonso
  • Helene Eltchaninoff
  • Lars Søndergaard
  • Dominique Himbert
  • Oliver Husser
  • Azeem Latib
  • Hervé Le Breton
  • Clement Servoz
  • Isaac Pascual
  • Saif Siddiqui
  • Paolo Olivares
  • Rosana Hernandez-Antolin
  • John G Webb
  • Sandro Sponga
  • Raj Makkar
  • Annapoorna S Kini
  • Marouane Boukhris
  • Philippe Gervais
  • Axel Linke
  • Lisa Crusius
  • David Holzhey
  • Josep Rodés-Cabau
Vis graf over relationer

Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation ≥2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p <0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p <0.001) and septic shock (adjusted p <0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation ≥2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up.

OriginalsprogEngelsk
TidsskriftThe American journal of cardiology
Vol/bind172
Sider (fra-til)90-97
Antal sider8
ISSN0002-9149
DOI
StatusUdgivet - 1 jun. 2022

Bibliografisk note

Copyright © 2022 Elsevier Inc. All rights reserved.

ID: 78316830