Mitochondrial dysfunction underlying outer retinal diseases

Evy Lefevere, Anne Katrine Toft-Kehler, Rupali Vohra, Miriam Kolko, Lieve Moons, Inge Van Hove

Abstrakt

Dysfunction of photoreceptors, retinal pigment epithelium (RPE) or both contribute to the initiation and progression of several outer retinal disorders. Disrupted Müller glia function might additionally subsidize to these diseases. Mitochondrial malfunctioning is importantly associated with outer retina pathologies, which can be classified as primary and secondary mitochondrial disorders. This review highlights the importance of oxidative stress and mitochondrial DNA damage, underlying outer retinal disorders. Indeed, the metabolically active photoreceptors/RPE are highly prone to these hallmarks of mitochondrial dysfunction, indicating that mitochondria represent a weak link in the antioxidant defenses of outer retinal cells.

OriginalsprogEngelsk
TidsskriftMitochondrion
Vol/bind36
Sider (fra-til)66-76
Antal sider11
ISSN1567-7249
DOI
StatusUdgivet - 2017

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