TY - JOUR
T1 - Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases
AU - Madsen, Helena Borland
AU - Durhuus, Jon Ambæk
AU - Andersen, Ove
AU - Straten, Per Thor
AU - Rahbech, Anne
AU - Desler, Claus
N1 - © 2024. The Author(s).
PY - 2024/12/4
Y1 - 2024/12/4
N2 - The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.
AB - The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.
UR - http://www.scopus.com/inward/record.url?scp=105010963616&partnerID=8YFLogxK
U2 - 10.1038/s44324-024-00038-x
DO - 10.1038/s44324-024-00038-x
M3 - Review
C2 - 40603504
SN - 2948-2828
VL - 2
SP - 36
JO - npj metabolic health and disease..
JF - npj metabolic health and disease..
IS - 1
M1 - 36
ER -