TY - JOUR
T1 - Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm
AU - Arnfred, Sidse Marie
AU - Lind, Nanna Marie
AU - Moustgaard, Anette Caroline
AU - Hansen, Axel Kornerup
AU - Gjedde, Albert
PY - 2003/9/1
Y1 - 2003/9/1
N2 - The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.
AB - The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.
KW - Acoustic Stimulation
KW - Animals
KW - Discrimination (Psychology)
KW - Discrimination Learning
KW - Electroencephalography
KW - Event-Related Potentials, P300
KW - Evoked Potentials, Auditory
KW - Male
KW - Swine
KW - Swine, Miniature
M3 - Journal article
C2 - 14527619
SN - 1053-8119
VL - 20
SP - 587
EP - 590
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -