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Region Hovedstaden - en del af Københavns Universitetshospital
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Mining the granule proteome: a potential source of endocrine biomarkers

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  1. Biomarkers and Their Relation to Cardiac Function Late After Peripartum Cardiomyopathy

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Vis graf over relationer

Proteomics of secretory granules is an emerging strategy for identifying secreted proteins, including potentially novel candidate biomarkers and peptide hormones. In addition, proteomics can provide information about the abundance, localization and structure (post-translational modification) of granule proteins and peptides. Analytical strategies within this research line include so-called 'subtractive proteomics', 'peptidomics' and granule purification by the use of multiple gradient centrifugations. Here we review the literature, and describe the challenges and opportunities in proteomics of secretory granules.

OriginalsprogEngelsk
TidsskriftBiomarkers in Medicine
Vol/bind9
Udgave nummer3
Sider (fra-til)259-65
Antal sider7
ISSN1752-0363
DOI
StatusUdgivet - 2015

ID: 45920120