Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

Jammbe Z Musoro; Corneel Coens; Susanne Singer; Silke Tribius; Sjoukje F Oosting; Mogens Groenvold; Christian Simon; Jean-Pascal Machiels; Vincent Grégoire; Galina Velikova; Kim Cocks; Mirjam A G Sprangers; Madeleine T King; Andrew Bottomley

doi:10.1002/hed.26363

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

Jammbe Z Musoro, Corneel Coens, Susanne Singer, Silke Tribius, Sjoukje F Oosting, Mogens Groenvold, Christian Simon, Jean-Pascal Machiels, Vincent Grégoire, Galina Velikova, Kim Cocks, Mirjam A G Sprangers, Madeleine T King, Andrew Bottomley

Geriatrisk og Palliativ Afdeling BFH

39 Citationer (Scopus)

Abstract

BACKGROUND: We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer.

METHODS: Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. MIDs for within-group and between-group change were estimated via the mean change method and linear regression, respectively. Distribution-based MIDs were also examined. MIDs for two of the scales, dyspnea and nausea/vomiting, are more uncertain considering their low correlations with the anchors.

RESULTS: Anchor-based MIDs could be determined for deterioration in 7 of the 14 QLQ-C30 scales assessed, and in 3 scales for improvement. MIDs varied by scale, direction of change, and anchor. Absolute MID values ranged from 5 to 15 points for within-group change and 4 to 12 for between-group change. Most MIDs were within 4 to 10 points.

CONCLUSIONS: Our findings, if confirmed, will aid interpreting changes in selected QLQ-C30 scale scores over time and inform sample size calculations in future clinical trials in head and neck cancer.

Originalsprog	Engelsk
Tidsskrift	Head and Neck
Vol/bind	42
Udgave nummer	11
Sider (fra-til)	3141-3152
Antal sider	12
ISSN	1043-3074
DOI	https://doi.org/10.1002/hed.26363
Status	Udgivet - nov. 2020

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Musoro, J. Z., Coens, C., Singer, S., Tribius, S., Oosting, S. F., Groenvold, M., Simon, C., Machiels, J.-P., Grégoire, V., Velikova, G., Cocks, K., Sprangers, M. A. G., King, M. T., & Bottomley, A. (2020). Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer. Head and Neck, 42(11), 3141-3152. https://doi.org/10.1002/hed.26363

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer. / Musoro, Jammbe Z; Coens, Corneel; Singer, Susanne et al.
I: Head and Neck, Bind 42, Nr. 11, 11.2020, s. 3141-3152.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Musoro, JZ, Coens, C, Singer, S, Tribius, S, Oosting, SF, Groenvold, M, Simon, C, Machiels, J-P, Grégoire, V, Velikova, G, Cocks, K, Sprangers, MAG, King, MT & Bottomley, A 2020, 'Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer', Head and Neck, bind 42, nr. 11, s. 3141-3152. https://doi.org/10.1002/hed.26363

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abstract = "BACKGROUND: We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer.METHODS: Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. MIDs for within-group and between-group change were estimated via the mean change method and linear regression, respectively. Distribution-based MIDs were also examined. MIDs for two of the scales, dyspnea and nausea/vomiting, are more uncertain considering their low correlations with the anchors.RESULTS: Anchor-based MIDs could be determined for deterioration in 7 of the 14 QLQ-C30 scales assessed, and in 3 scales for improvement. MIDs varied by scale, direction of change, and anchor. Absolute MID values ranged from 5 to 15 points for within-group change and 4 to 12 for between-group change. Most MIDs were within 4 to 10 points.CONCLUSIONS: Our findings, if confirmed, will aid interpreting changes in selected QLQ-C30 scale scores over time and inform sample size calculations in future clinical trials in head and neck cancer.",

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T1 - Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

AU - Musoro, Jammbe Z

AU - Coens, Corneel

AU - Singer, Susanne

AU - Tribius, Silke

AU - Oosting, Sjoukje F

AU - Groenvold, Mogens

AU - Simon, Christian

AU - Machiels, Jean-Pascal

AU - Grégoire, Vincent

AU - Velikova, Galina

AU - Cocks, Kim

AU - Sprangers, Mirjam A G

AU - King, Madeleine T

AU - Bottomley, Andrew

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N2 - BACKGROUND: We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer.METHODS: Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. MIDs for within-group and between-group change were estimated via the mean change method and linear regression, respectively. Distribution-based MIDs were also examined. MIDs for two of the scales, dyspnea and nausea/vomiting, are more uncertain considering their low correlations with the anchors.RESULTS: Anchor-based MIDs could be determined for deterioration in 7 of the 14 QLQ-C30 scales assessed, and in 3 scales for improvement. MIDs varied by scale, direction of change, and anchor. Absolute MID values ranged from 5 to 15 points for within-group change and 4 to 12 for between-group change. Most MIDs were within 4 to 10 points.CONCLUSIONS: Our findings, if confirmed, will aid interpreting changes in selected QLQ-C30 scale scores over time and inform sample size calculations in future clinical trials in head and neck cancer.

AB - BACKGROUND: We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer.METHODS: Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. MIDs for within-group and between-group change were estimated via the mean change method and linear regression, respectively. Distribution-based MIDs were also examined. MIDs for two of the scales, dyspnea and nausea/vomiting, are more uncertain considering their low correlations with the anchors.RESULTS: Anchor-based MIDs could be determined for deterioration in 7 of the 14 QLQ-C30 scales assessed, and in 3 scales for improvement. MIDs varied by scale, direction of change, and anchor. Absolute MID values ranged from 5 to 15 points for within-group change and 4 to 12 for between-group change. Most MIDs were within 4 to 10 points.CONCLUSIONS: Our findings, if confirmed, will aid interpreting changes in selected QLQ-C30 scale scores over time and inform sample size calculations in future clinical trials in head and neck cancer.

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KW - head and neck cancer

KW - health-related quality of life

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JO - Head and Neck

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Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

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