Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

Hyunggug Kim, Seongyeon Kim, Nam Suk Sim, Cristina Pasquinelli, Axel Thielscher, Jeong Ho Lee, Hyunjoo J Lee

43 Citationer (Scopus)

Abstract

BACKGROUND: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers.

METHODS: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice.

RESULTS: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states.

CONCLUSION: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.

OriginalsprogEngelsk
TidsskriftBrain Stimulation
Vol/bind12
Udgave nummer2
Sider (fra-til)251-255
Antal sider5
ISSN1935-861X
DOI
StatusUdgivet - mar. 2019

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