Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

Maxime Descoteaux; Kurt G Schilling; Dogu Baran Aydogan; Christian Beaulieu; Elena Borra; Maxime Chamberland; Alessandro Daducci; Alberto De Luca; Flavio Dell'Acqua; Jessica Dubois; Tim B Dyrby; Shawna Farquharson; Stephanie Forkel; Martijn Froeling; Alessandra Griffa; Mareike Grotheer; Pamela Guevara; Suzanne N Haber; Vinod Kumar Jangir; Alexander Leemans; Joël Lefebvre; Ching-Po Lin; Graham Little; Chun-Yi Zac Lo; Chiara Maffei; Helen S Mayberg; Jennifer A McNab; Pratik Mukherjee; Lauren J O'Donnell; Martin Parent; Carlo Pierpaoli; Francois Rheault; Kathleen S Rockland; Alard Roebroeck; Ariel Rokem; R Jarrett Rushmore; Silvio Sarubbo; Simona Schiavi; Stamatios N Sotiropoulos; Diego Szczupak; Michel Thiebaut de Schotten; J-Donald Tournier; Francesco Vergani; Joseph Yuan-Mou Yang; Fan Zhang; Derek Jones; Laurent Petit

doi:10.48550/arXiv.2509.26259

Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

Maxime Descoteaux, Kurt G Schilling, Dogu Baran Aydogan, Christian Beaulieu, Elena Borra, Maxime Chamberland, Alessandro Daducci, Alberto De Luca, Flavio Dell'Acqua, Jessica Dubois, Tim B Dyrby, Shawna Farquharson, Stephanie Forkel, Martijn Froeling, Alessandra Griffa, Mareike Grotheer, Pamela Guevara, Suzanne N Haber, Vinod Kumar Jangir, Alexander LeemansJoël Lefebvre, Ching-Po Lin, Graham Little, Chun-Yi Zac Lo, Chiara Maffei, Helen S Mayberg, Jennifer A McNab, Pratik Mukherjee, Lauren J O'Donnell, Martin Parent, Carlo Pierpaoli, Francois Rheault, Kathleen S Rockland, Alard Roebroeck, Ariel Rokem, R Jarrett Rushmore, Silvio Sarubbo, Simona Schiavi, Stamatios N Sotiropoulos, Diego Szczupak, Michel Thiebaut de Schotten, J-Donald Tournier, Francesco Vergani, Joseph Yuan-Mou Yang, Fan Zhang, Derek Jones, Laurent Petit

Abstract

In the spirit of the historic Millennium Prize Problems that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the Millennium Pathways for Tractography, a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural Tract-Anat Retreat, this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the Millennium Pathways aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.

Originalsprog	Engelsk
DOI	https://doi.org/10.48550/arXiv.2509.26259
Status	Udgivet - 30 sep. 2025

Navn	ArXiv
ISSN	2331-8422

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10.48550/arXiv.2509.26259Licens: CC BY

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Descoteaux, M., Schilling, K. G., Aydogan, D. B., Beaulieu, C., Borra, E., Chamberland, M., Daducci, A., Luca, A. D., Dell'Acqua, F., Dubois, J., Dyrby, T. B., Farquharson, S., Forkel, S., Froeling, M., Griffa, A., Grotheer, M., Guevara, P., Haber, S. N., Jangir, V. K., ... Petit, L. (2025). Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography. ArXiv https://doi.org/10.48550/arXiv.2509.26259

Descoteaux, M, Schilling, KG, Aydogan, DB, Beaulieu, C, Borra, E, Chamberland, M, Daducci, A, Luca, AD, Dell'Acqua, F, Dubois, J, Dyrby, TB, Farquharson, S, Forkel, S, Froeling, M, Griffa, A, Grotheer, M, Guevara, P, Haber, SN, Jangir, VK, Leemans, A, Lefebvre, J, Lin, C-P, Little, G, Zac Lo, C-Y, Maffei, C, Mayberg, HS, McNab, JA, Mukherjee, P, O'Donnell, LJ, Parent, M, Pierpaoli, C, Rheault, F, Rockland, KS, Roebroeck, A, Rokem, A, Rushmore, RJ, Sarubbo, S, Schiavi, S, Sotiropoulos, SN, Szczupak, D, de Schotten, MT, Tournier, J-D, Vergani, F, Yuan-Mou Yang, J, Zhang, F, Jones, D & Petit, L 2025 'Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography' ArXiv. https://doi.org/10.48550/arXiv.2509.26259

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abstract = "In the spirit of the historic Millennium Prize Problems that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the Millennium Pathways for Tractography, a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural Tract-Anat Retreat, this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the Millennium Pathways aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.",

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AU - Chamberland, Maxime

AU - Daducci, Alessandro

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AU - Dell'Acqua, Flavio

AU - Dubois, Jessica

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AB - In the spirit of the historic Millennium Prize Problems that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the Millennium Pathways for Tractography, a community-driven roadmap designed to shape the future of the field. Conceived during the inaugural Tract-Anat Retreat, this initiative reflects a collective vision for advancing tractography over the coming decade and beyond. The roadmap consists of 40 grand challenges, developed by international experts and organized into seven categories spanning three overarching themes: neuroanatomy, tractography methods, and clinical applications. By defining shared short-, medium-, and long-term goals, these pathways provide a structured framework to confront fundamental limitations, promote rigorous validation, and accelerate the translation of tractography into a robust tool for neuroscience and medicine. Ultimately, the Millennium Pathways aim to guide and inspire future research and collaboration, ensuring the continued scientific and clinical relevance of tractography well into the future.

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ER -

Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

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