Mikroalbuminuri som praediktor af aterosklerotisk kardiovaskulaer sygdom ved IDDM

T Deckert, H Yokoyama, E R Mathiesen, B Rønn, T J Jensen, B F Feldt-Rasmussen, K Borch-Johnsen, J S Jensen

Abstract

The aim of this follow-up study was to assess whether slightly elevated urinary albumin excretion, i.e., microalbuminuria, precedes development of atherosclerotic vascular disease in IDDM. Out of 259 IDDM-patients 30 developed vascular disease during 2,457 person-years. Microalbuminuria was significantly predictive of vascular disease (hazard ratio (95% confidence interval) 1.06 (1.02-1.18) per 5 mg/24 hours increase in urinary albumin excretion; p = 0.002). The predictive effect was independent of age, sex, blood pressure, tobacco smoking, serum concentrations of total-cholesterol, HDL-cholesterol, sialic acid, and von Willebrand factor, and of haemoglobin A1c, insulin dose, diabetes duration, and diabetic nephropathy (hazard ratio (95% confidence interval) 1.04 (1.01-1.08) per 5 mg/24 hours increase in urinary albumin excretion; p = 0.03). It is concluded that slightly elevated urinary albumin excretion is an independent predictor of atherosclerotic vascular disease in insulin-dependent diabetes mellitus.

Bidragets oversatte titelMicroalbuminuria as predictor of atherosclerotic cardiovascular disease in IDDM
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind159
Udgave nummer20
Sider (fra-til)3010-4
Antal sider5
ISSN0041-5782
StatusUdgivet - 12 maj 1997

Emneord

  • Adult
  • Albuminuria
  • Arteriosclerosis
  • Cohort Studies
  • Diabetes Mellitus, Type 1
  • Diabetic Angiopathies
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Prognosis

Fingeraftryk

Dyk ned i forskningsemnerne om 'Mikroalbuminuri som praediktor af aterosklerotisk kardiovaskulaer sygdom ved IDDM'. Sammen danner de et unikt fingeraftryk.

Citationsformater