Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{31b45535cfb44e4c909a759d7704367b,
title = "Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging",
abstract = "Purpose: To describe the migration of an outer retinal element using longitudinal multimodal imaging.Observations: In the retina of a healthy 7-year-old girl, movement of a hyperreflective element of 15 μm extent was seen using optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (cSLO), and adaptive optics fundus photography (AO). On the OCT B-scan, the element initially appeared at the level of the outer limiting membrane with an umbra reaching the retinal pigment epithelium from where it gradually diminished and disappeared over 33 days. A corresponding disruption of the photoreceptor pattern on AO diminished over 52 days.Conclusions and importance: This non-invasive observation of an isolated, cell-sized, migrating element in the human retina was made in vivo in the absence of confounding retinal disease or similar nearby elements. Based on prior preclinical observations we hypothesize that such a migrating element could be a macrophage. The case provides information about the time-scale and resolution needed for the monitoring of infiltrative processes in the retina.",
keywords = "Adaptive optics, Confocal scanning laser ophthalmoscopy, Longitudinal multimodal imaging, Migrating element, Optical coherence tomography, Retina",
author = "Torm, {Marie Elise Wistrup} and Mohamed Belmouhand and Munch, {Inger Christine} and Michael Larsen and Rothenbuehler, {Simon Paul}",
note = "{\textcopyright} 2020 The Authors.",
year = "2020",
month = jun,
doi = "10.1016/j.ajoc.2020.100637",
language = "English",
volume = "18",
pages = "100637",
journal = "American Journal of Ophthalmology Case Reports",
issn = "2451-9936",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

AU - Torm, Marie Elise Wistrup

AU - Belmouhand, Mohamed

AU - Munch, Inger Christine

AU - Larsen, Michael

AU - Rothenbuehler, Simon Paul

N1 - © 2020 The Authors.

PY - 2020/6

Y1 - 2020/6

N2 - Purpose: To describe the migration of an outer retinal element using longitudinal multimodal imaging.Observations: In the retina of a healthy 7-year-old girl, movement of a hyperreflective element of 15 μm extent was seen using optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (cSLO), and adaptive optics fundus photography (AO). On the OCT B-scan, the element initially appeared at the level of the outer limiting membrane with an umbra reaching the retinal pigment epithelium from where it gradually diminished and disappeared over 33 days. A corresponding disruption of the photoreceptor pattern on AO diminished over 52 days.Conclusions and importance: This non-invasive observation of an isolated, cell-sized, migrating element in the human retina was made in vivo in the absence of confounding retinal disease or similar nearby elements. Based on prior preclinical observations we hypothesize that such a migrating element could be a macrophage. The case provides information about the time-scale and resolution needed for the monitoring of infiltrative processes in the retina.

AB - Purpose: To describe the migration of an outer retinal element using longitudinal multimodal imaging.Observations: In the retina of a healthy 7-year-old girl, movement of a hyperreflective element of 15 μm extent was seen using optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (cSLO), and adaptive optics fundus photography (AO). On the OCT B-scan, the element initially appeared at the level of the outer limiting membrane with an umbra reaching the retinal pigment epithelium from where it gradually diminished and disappeared over 33 days. A corresponding disruption of the photoreceptor pattern on AO diminished over 52 days.Conclusions and importance: This non-invasive observation of an isolated, cell-sized, migrating element in the human retina was made in vivo in the absence of confounding retinal disease or similar nearby elements. Based on prior preclinical observations we hypothesize that such a migrating element could be a macrophage. The case provides information about the time-scale and resolution needed for the monitoring of infiltrative processes in the retina.

KW - Adaptive optics

KW - Confocal scanning laser ophthalmoscopy

KW - Longitudinal multimodal imaging

KW - Migrating element

KW - Optical coherence tomography

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=85080109471&partnerID=8YFLogxK

U2 - 10.1016/j.ajoc.2020.100637

DO - 10.1016/j.ajoc.2020.100637

M3 - Journal article

C2 - 32154438

VL - 18

SP - 100637

JO - American Journal of Ophthalmology Case Reports

JF - American Journal of Ophthalmology Case Reports

SN - 2451-9936

M1 - 100637

ER -

ID: 62051791