Migraine: disease characterisation, biomarkers, and precision medicine

Messoud Ashina, Gisela M Terwindt, Mohammad Al-Mahdi Al-Karagholi, Irene de Boer, Mi Ji Lee, Debbie L Hay, Laura H Schulte, Nouchine Hadjikhani, Alexandra J Sinclair, Håkan Ashina, Todd J Schwedt, Peter J Goadsby

Abstract

Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria. A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine, including the underlying genetic and neurobiological factors. This complexity has generated momentum for biomarker research to improve disease characterisation and identify novel drug targets. In this Series paper, we present the progress that has been made in the search for biomarkers of migraine within genetics, provocation modelling, biochemistry, and neuroimaging research. Additionally, we outline challenges and future directions for each biomarker modality. We also discuss the advances made in combining and integrating data from multiple biomarker modalities. These efforts contribute to developing precision medicine that can be applied to future patients with migraine.

OriginalsprogEngelsk
TidsskriftThe Lancet
Vol/bind397
Udgave nummer10283
Sider (fra-til)1496-1504
Antal sider9
ISSN0140-6736
DOI
StatusUdgivet - 2021

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