TY - JOUR
T1 - Migraine and risk of hemorrhagic stroke
T2 - a study based on data from general practice
AU - Gaist, David
AU - González-Pérez, Antonio
AU - Ashina, Messoud
AU - Rodríguez, Luis Alberto García
PY - 2014
Y1 - 2014
N2 - BACKGROUND: We investigated the association between hemorrhagic stroke and migraine using data from The Health Improvement Network database.FINDINGS: We ascertained 1,797 incident cases of intracerebral hemorrhage (ICH) and 1,340 of subarachnoid hemorrhage (SAH). Density-based sampling was used to select 10,000 controls free from hemorrhagic stroke. Using unconditional logistic regression models, we calculated the risk of hemorrhagic stroke associated with migraine, adjusting for age, sex, calendar year, alcohol, body mass index, hypertension, previous cerebrovascular disease, oral contraceptive use, and health services utilization.The risk (odds ratio [OR]) of ICH among migraineurs was 1.2 (95% confidence interval [CI] 0.9-1.5), and of SAH was (1.2, 95% CI 0.9-1.5). The association with ICH was stronger for migraine diagnosed ≥20 years prior to ICH (OR 1.6, 95% CI 1.0-2.4), but not with SAH (OR 1.1, 95% CI 0.6-2.1). In analyses stratified by migraine type and gender, the OR of ICH in women with migraine with aura was 1.7 (95% CI 0.9-3.4) and the corresponding OR of SAH in women was 1.2 (95% CI 0.6-2.3).CONCLUSION: No clear increased risk of ICH or SAH was observed in migraineurs.
AB - BACKGROUND: We investigated the association between hemorrhagic stroke and migraine using data from The Health Improvement Network database.FINDINGS: We ascertained 1,797 incident cases of intracerebral hemorrhage (ICH) and 1,340 of subarachnoid hemorrhage (SAH). Density-based sampling was used to select 10,000 controls free from hemorrhagic stroke. Using unconditional logistic regression models, we calculated the risk of hemorrhagic stroke associated with migraine, adjusting for age, sex, calendar year, alcohol, body mass index, hypertension, previous cerebrovascular disease, oral contraceptive use, and health services utilization.The risk (odds ratio [OR]) of ICH among migraineurs was 1.2 (95% confidence interval [CI] 0.9-1.5), and of SAH was (1.2, 95% CI 0.9-1.5). The association with ICH was stronger for migraine diagnosed ≥20 years prior to ICH (OR 1.6, 95% CI 1.0-2.4), but not with SAH (OR 1.1, 95% CI 0.6-2.1). In analyses stratified by migraine type and gender, the OR of ICH in women with migraine with aura was 1.7 (95% CI 0.9-3.4) and the corresponding OR of SAH in women was 1.2 (95% CI 0.6-2.3).CONCLUSION: No clear increased risk of ICH or SAH was observed in migraineurs.
U2 - 10.1186/1129-2377-15-74
DO - 10.1186/1129-2377-15-74
M3 - Journal article
C2 - 25387444
SN - 1129-2369
VL - 15
SP - 74
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
ER -