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Region Hovedstaden - en del af Københavns Universitetshospital
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MicroRNA Related Polymorphisms and Breast Cancer Risk

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hepatitis C prevalence in Denmark in 2016-An updated estimate using multiple national registers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Lipidomics of human adipose tissue reveals diversity between body areas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impact of cardiovascular risk factors and genetics on 10-year absolute risk of dementia: risk charts for targeted prevention

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Sofia Khan
  • Dario Greco
  • Kyriaki Michailidou
  • Roger L Milne
  • Taru A Muranen
  • Tuomas Heikkinen
  • Kirsimari Aaltonen
  • Joe Dennis
  • Manjeet K Bolla
  • Jianjun Liu
  • Per Hall
  • Astrid Irwanto
  • Keith Humphreys
  • Jingmei Li
  • Kamila Czene
  • Jenny Chang-Claude
  • Rebecca Hein
  • Anja Rudolph
  • Petra Seibold
  • Dieter Flesch-Janys
  • Olivia Fletcher
  • Julian Peto
  • Isabel Dos Santos Silva
  • Nichola Johnson
  • Lorna Gibson
  • Zoe Aitken
  • John L Hopper
  • Helen Tsimiklis
  • Minh Bui
  • Enes Makalic
  • Daniel F Schmidt
  • Melissa C Southey
  • Carmel Apicella
  • Jennifer Stone
  • Quinten Waisfisz
  • Hanne Meijers-Heijboer
  • Muriel A Adank
  • Rob B van der Luijt
  • Alfons Meindl
  • Rita K Schmutzler
  • Bertram Müller-Myhsok
  • Peter Lichtner
  • Clare Turnbull
  • Nazneen Rahman
  • Stephen J Chanock
  • David J Hunter
  • Stig E Bojesen
  • Børge G Nordestgaard
  • Sune F Nielsen
  • Henrik Flyger
  • kConFab Investigators
Vis graf over relationer

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and may alter individual susceptibility to cancer. We investigated associations between miRNA related SNPs and breast cancer risk. First we evaluated 2,196 SNPs in a case-control study combining nine genome wide association studies (GWAS). Second, we further investigated 42 SNPs with suggestive evidence for association using 41,785 cases and 41,880 controls from 41 studies included in the Breast Cancer Association Consortium (BCAC). Combining the GWAS and BCAC data within a meta-analysis, we estimated main effects on breast cancer risk as well as risks for estrogen receptor (ER) and age defined subgroups. Five miRNA binding site SNPs associated significantly with breast cancer risk: rs1045494 (odds ratio (OR) 0.92; 95% confidence interval (CI): 0.88-0.96), rs1052532 (OR 0.97; 95% CI: 0.95-0.99), rs10719 (OR 0.97; 95% CI: 0.94-0.99), rs4687554 (OR 0.97; 95% CI: 0.95-0.99, and rs3134615 (OR 1.03; 95% CI: 1.01-1.05) located in the 3' UTR of CASP8, HDDC3, DROSHA, MUSTN1, and MYCL1, respectively. DROSHA belongs to miRNA machinery genes and has a central role in initial miRNA processing. The remaining genes are involved in different molecular functions, including apoptosis and gene expression regulation. Further studies are warranted to elucidate whether the miRNA binding site SNPs are the causative variants for the observed risk effects.

OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind9
Udgave nummer11
Sider (fra-til)e109973
ISSN1932-6203
DOI
StatusUdgivet - 2014

ID: 44706402