MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease

Christoffer Hother; Peter Kristian Rasmussen; Tejal Joshi; Ditte Reker; Ulrik Ralfkiær; Christopher Workman; Steffen Heegaard; Elisabeth Ralfkiær; Kirsten Grønbæk

doi:10.1167/iovs.13-12272

MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease

Christoffer Hother, Peter Kristian Rasmussen, Tejal Joshi, Ditte Reker, Ulrik Ralfkiær, Christopher Workman, Steffen Heegaard, Elisabeth Ralfkiær, Kirsten Grønbæk

30 Citationer (Scopus)

Abstract

Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease.

Originalsprog	Engelsk
Tidsskrift	Investigative ophthalmology & visual science
Vol/bind	54
Udgave nummer	8
Sider (fra-til)	5169-75
Antal sider	7
ISSN	0146-0404
DOI	https://doi.org/10.1167/iovs.13-12272
Status	Udgivet - aug. 2013

Adgang til dokumentet

10.1167/iovs.13-12272

Citationsformater

Hother, C., Rasmussen, P. K., Joshi, T., Reker, D., Ralfkiær, U., Workman, C., Heegaard, S., Ralfkiær, E., & Grønbæk, K. (2013). MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease. Investigative ophthalmology & visual science, 54(8), 5169-75. https://doi.org/10.1167/iovs.13-12272

MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease. / Hother, Christoffer; Rasmussen, Peter Kristian; Joshi, Tejal et al.
I: Investigative ophthalmology & visual science, Bind 54, Nr. 8, 08.2013, s. 5169-75.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hother, C, Rasmussen, PK, Joshi, T, Reker, D, Ralfkiær, U, Workman, C, Heegaard, S, Ralfkiær, E & Grønbæk, K 2013, 'MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease', Investigative ophthalmology & visual science, bind 54, nr. 8, s. 5169-75. https://doi.org/10.1167/iovs.13-12272

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title = "MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease",

abstract = "Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease.",

keywords = "Adult, Aged, Aged, 80 and over, Conjunctival Neoplasms, Eye Neoplasms, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Lacrimal Apparatus, Lymphoma, Large B-Cell, Diffuse, Male, MicroRNAs, Middle Aged, NF-kappa B p50 Subunit, Orbital Neoplasms, Protein Array Analysis, Proto-Oncogene Proteins c-myc, RNA, Neoplasm, Real-Time Polymerase Chain Reaction",

author = "Christoffer Hother and Rasmussen, {Peter Kristian} and Tejal Joshi and Ditte Reker and Ulrik Ralfki{\ae}r and Christopher Workman and Steffen Heegaard and Elisabeth Ralfki{\ae}r and Kirsten Gr{\o}nb{\ae}k",

year = "2013",

month = aug,

doi = "10.1167/iovs.13-12272",

language = "English",

volume = "54",

pages = "5169--75",

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AU - Hother, Christoffer

AU - Rasmussen, Peter Kristian

AU - Joshi, Tejal

AU - Reker, Ditte

AU - Ralfkiær, Ulrik

AU - Workman, Christopher

AU - Heegaard, Steffen

AU - Ralfkiær, Elisabeth

AU - Grønbæk, Kirsten

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N2 - Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease.

AB - Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Conjunctival Neoplasms

KW - Eye Neoplasms

KW - Female

KW - Follow-Up Studies

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Lacrimal Apparatus

KW - Lymphoma, Large B-Cell, Diffuse

KW - Male

KW - MicroRNAs

KW - Middle Aged

KW - NF-kappa B p50 Subunit

KW - Orbital Neoplasms

KW - Protein Array Analysis

KW - Proto-Oncogene Proteins c-myc

KW - RNA, Neoplasm

KW - Real-Time Polymerase Chain Reaction

U2 - 10.1167/iovs.13-12272

DO - 10.1167/iovs.13-12272

M3 - Journal article

C2 - 23821202

SN - 0146-0404

VL - 54

SP - 5169

EP - 5175

JO - Investigative ophthalmology & visual science

JF - Investigative ophthalmology & visual science

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ER -

MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease

Abstract

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