MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease

Christoffer Hother, Peter Kristian Rasmussen, Tejal Joshi, Ditte Reker, Ulrik Ralfkiær, Christopher Workman, Steffen Heegaard, Elisabeth Ralfkiær, Kirsten Grønbæk

23 Citationer (Scopus)

Abstrakt

Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease.
OriginalsprogEngelsk
TidsskriftInvestigative ophthalmology & visual science
Vol/bind54
Udgave nummer8
Sider (fra-til)5169-75
Antal sider7
ISSN0146-0404
DOI
StatusUdgivet - aug. 2013

Fingeraftryk

Dyk ned i forskningsemnerne om 'MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease'. Sammen danner de et unikt fingeraftryk.

Citationsformater