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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

MicroRNA miR-125b induces senescence in human melanoma cells

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Vis graf over relationer
MicroRNAs (miRNAs) are small noncoding RNA molecules involved in gene regulation. Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. In a previous study, we found that the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melanoma producing lymph node micrometastases than in nonmetastasizing tumors. To get further insight into the functional role of miR-125b, we assessed whether its overexpression or silencing affects apoptosis, proliferation, or senescence in melanoma cell lines. We showed that overexpression of miR-125b induced typical senescent cell morphology, including increased cytoplasmatic/nucleus ratio and intensive cytoplasmatic β-galactosidase expression. In contrast, inhibition of miR-125b resulted in 30-35% decreased levels of spontaneous apoptosis. We propose that downregulation of miR-125b in an early cutaneous malignant melanoma can contribute to the increased metastatic capability of this tumor.
OriginalsprogEngelsk
TidsskriftMelanoma Research
Vol/bind21
Udgave nummer3
Sider (fra-til)253-6
Antal sider4
ISSN0960-8931
DOI
StatusUdgivet - 1 jun. 2011

ID: 32227609