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Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors

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  2. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Kim Pc Kuypers
  • Livia Ng
  • David Erritzoe
  • Gitte M Knudsen
  • Charles D Nichols
  • David E Nichols
  • Luca Pani
  • Anaïs Soula
  • David Nutt
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BACKGROUND: In the past few years, the issue of 'microdosing' psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cognitive processes such as concentration. However, there are very few scientific studies that have specifically addressed this issue, and there is no agreed scientific consensus on what microdosing is.

AIM: This critique paper is designed to address questions that need to be answered by future scientific studies and to offer guidelines for these studies.

APPROACH: Owing to its proximity for a possible approval in clinical use and short-lasting pharmacokinetics, our focus is predominantly on psilocybin. Psilocybin is allegedly, next to lysergic acid diethylamide (LSD), one of the two most frequently used psychedelics to microdose. Where relevant and available, data for other psychedelic drugs are also mentioned.

CONCLUSION: It is concluded that while most anecdotal reports focus on the positive experiences with microdosing, future research should also focus on potential risks of (multiple) administrations of a psychedelic in low doses. To that end, (pre)clinical studies including biological (e.g. heart rate, receptor turnover and occupancy) as well as cognitive (e.g. memory, attention) parameters have to be conducted and will shed light on the potential negative consequences microdosing could have.

OriginalsprogEngelsk
TidsskriftJournal of psychopharmacology (Oxford, England)
Vol/bind33
Udgave nummer9
Sider (fra-til)1039-1057
Antal sider19
ISSN0269-8811
DOI
StatusUdgivet - sep. 2019

ID: 59012480