Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Metronidazole elimination is preserved in the elderly

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Methylphenidate misuse in adult patients and the impact of therapeutic use

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Time-response relationship of nano and micro particle induced lung inflammation. Quartz as reference compound

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effect of theophylline and salbutamol on hepatic drug metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Influence of age and consumption of tobacco, alcohol and caffeine on antipyrine clearance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

1 The disposition of metronidazole and its major metabolites was compared in 11 subjects aged 86 +/- 6 years and 8 aged 30 +/- 6 years. 2 The plasma clearance of metronidazole was 1.20 +/- 0.53 and 1.25 +/- 0.22 ml min-1 kg-1, the volume of distribution 0.77 +/- 0.27 and 0.77 +/- 0.09 1 kg-1 and the half-life 7.8 +/- 1.9 and 7.2 +/- 0.9 h in elderly and young subjects, respectively (P less than 0.05). 3 The area under the plasma concentration-time curve of the hydroxy metabolite was 32 +/- 14 and 21 +/- 3 mM min-1 (P less than 0.05) whereas its half-life was 21 +/- 14 and 12 +/- 2 h (P less than 0.05) in the elderly and young subjects, respectively. 4 The recovery in the urine of metronidazole and its metabolites was 42 +/- 21% and 87 +/- 6% of dose in elderly and young subjects, respectively (P less than 0.05). With this reservation the only elimination pathways of metronidazole affected by old age were the renal excretion of unchanged compound and the hydroxy metabolite. 5 It is concluded that the ability to eliminate metronidazole is preserved in old age and that age-related dose adjustments are not necessary.

OriginalsprogEngelsk
TidsskriftHuman & Experimental Toxicology
Vol/bind9
Udgave nummer3
Sider (fra-til)155-9
Antal sider5
ISSN0960-3271
DOI
StatusUdgivet - maj 1990

ID: 67020366