TY - JOUR
T1 - Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A combined analysis of independent samples
AU - Saetre, Peter
AU - Vares, Maria
AU - Werge, Thomas
AU - Andreassen, Ole A
AU - Arinami, Tadao
AU - Ishiguro, Hiroki
AU - Nanko, Shinichiro
AU - Tan, Ene Choo
AU - Han, Doug Hyun
AU - Roffman, Joshua L
AU - Muntjewerff, Jan-Willem
AU - Jagodzinski, Pawel P
AU - Kempisty, Bartosz
AU - Hauser, Joanna
AU - Vilella, Elisabet
AU - Betcheva, Elitza
AU - Nakamura, Yusuke
AU - Regland, Björn
AU - Agartz, Ingrid
AU - Hall, Håkan
AU - Terenius, Lars
AU - Jönsson, Erik G
N1 - Copyright © 2011 Wiley-Liss, Inc.
PY - 2011/3
Y1 - 2011/3
N2 - Methylenetetrahydrofolate reductase (MTHFR) is involved in the one-carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes two common polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) which both alter enzyme activity. The T-allele of the C677T polymorphism has recently been associated with earlier age at onset of schizophrenia. In the present study we examined the association between the MTHFR C677T and A1298C polymorphisms and age at onset of schizophrenia in twelve samples consisting of 3,213 unrelated schizophrenia patients, including the original Scandinavian sample. There was no consistent relationship between MTHFR C677T, A1298C or combined 677T/1298C carriers and age of onset in schizophrenia when the results of each study were combined using meta-analysis. The present results suggest that the investigated MTHFR polymorphisms do not influence age of onset in schizophrenia. © 2011 Wiley-Liss, Inc.
AB - Methylenetetrahydrofolate reductase (MTHFR) is involved in the one-carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes two common polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) which both alter enzyme activity. The T-allele of the C677T polymorphism has recently been associated with earlier age at onset of schizophrenia. In the present study we examined the association between the MTHFR C677T and A1298C polymorphisms and age at onset of schizophrenia in twelve samples consisting of 3,213 unrelated schizophrenia patients, including the original Scandinavian sample. There was no consistent relationship between MTHFR C677T, A1298C or combined 677T/1298C carriers and age of onset in schizophrenia when the results of each study were combined using meta-analysis. The present results suggest that the investigated MTHFR polymorphisms do not influence age of onset in schizophrenia. © 2011 Wiley-Liss, Inc.
U2 - 10.1002/ajmg.b.31160
DO - 10.1002/ajmg.b.31160
M3 - Journal article
C2 - 21302350
SN - 1552-485X
VL - 156
SP - 215
EP - 224
JO - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
JF - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
IS - 2
ER -