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Region Hovedstaden - en del af Københavns Universitetshospital
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Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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  • Patrick Van Dijck
  • Jelmer Sjollema
  • Bruno P Cammue
  • Katrien Lagrou
  • Judith Berman
  • Christophe d'Enfert
  • David R Andes
  • Maiken C Arendrup
  • Axel A Brakhage
  • Richard Calderone
  • Emilia Cantón
  • Tom Coenye
  • Paul Cos
  • Leah E Cowen
  • Mira Edgerton
  • Ana Espinel-Ingroff
  • Scott G Filler
  • Mahmoud Ghannoum
  • Neil A R Gow
  • Hubertus Haas
  • Mary Ann Jabra-Rizk
  • Elizabeth M Johnson
  • Shawn R Lockhart
  • Jose L Lopez-Ribot
  • Johan Maertens
  • Carol A Munro
  • Jeniel E Nett
  • Clarissa J Nobile
  • Michael A Pfaller
  • Gordon Ramage
  • Dominique Sanglard
  • Maurizio Sanguinetti
  • Isabel Spriet
  • Paul E Verweij
  • Adilia Warris
  • Joost Wauters
  • Michael R Yeaman
  • Sebastian A J Zaat
  • Karin Thevissen
Vis graf over relationer

Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

OriginalsprogEngelsk
TidsskriftMicrobial Cell Factories
Vol/bind5
Udgave nummer7
Sider (fra-til)300-326
Antal sider27
ISSN2311-2638
DOI
StatusUdgivet - 14 jun. 2018

ID: 56271608