Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

Steen Larsen; R Rabøl; C N Hansen; S Madsbad; J W Helge; Flemming Dela

doi:10.1007/s00125-011-2340-0

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

Steen Larsen, R Rabøl, C N Hansen, S Madsbad, J W Helge, Flemming Dela

Endokrinologisk Forskningsenhed AHH

73 Citationer (Scopus)

Abstract

The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	2
Sider (fra-til)	443-9
Antal sider	7
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-011-2340-0
Status	Udgivet - 2012

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10.1007/s00125-011-2340-0

Citationsformater

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title = "Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration",

abstract = "The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.",

author = "Steen Larsen and R Rab{\o}l and Hansen, {C N} and S Madsbad and Helge, {J W} and Flemming Dela",

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T1 - Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

AU - Larsen, Steen

AU - Rabøl, R

AU - Hansen, C N

AU - Madsbad, S

AU - Helge, J W

AU - Dela, Flemming

PY - 2012

Y1 - 2012

N2 - The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.

AB - The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.

U2 - 10.1007/s00125-011-2340-0

DO - 10.1007/s00125-011-2340-0

M3 - Journal article

C2 - 22009334

SN - 0012-186X

VL - 55

SP - 443

EP - 449

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

Abstract

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