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Region Hovedstaden - en del af Københavns Universitetshospital
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Metabolic syndrome in first-time hospitalized patients with depression: a 1-year follow-up study

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  • L Nyboe
  • C H Vestergaard
  • H Lund
  • M K Møller
  • P Videbech
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OBJECTIVE: Studies on metabolic syndrome (MetS) in younger patients with depression are few. We examined the prevalence and progression of MetS in first-time hospitalized patients with depression during 1 year of follow-up. Furthermore, we explored putative risk factors of MetS.

METHOD: We evaluated MetS and its components in first-time hospitalized patients with depression (N = 52) and healthy controls (N = 50) (18-45 years). Physical activity, aerobic fitness, sleeping disturbances, smoking and dietary habits, and psychopharmacological treatment were recorded at baseline for all participants and after 1 year for the patients.

RESULTS: Patients had significantly higher waist circumference (WC) and lower high-density lipoproteins compared with healthy controls (P < 0.05). Patients had higher prevalence of MetS, but this was not significant when adjusted for age. Patients had significant increase in WC and triglycerides and a non-significant increase in the prevalence of MetS. Antipsychotic medication (OR 10.5, 95% CI 1.18-94.14) and low aerobic fitness (OR 0.79, 95% CI 0.68-0.93) were significantly correlated with MetS (P < 0.05).

CONCLUSION: Metabolic syndrome is highly prevalent in younger, severely depressed patients and the incidence increases during 1 year of follow-up. Low aerobic fitness and use of atypical antipsychotics are strongly correlated with MetS.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind133
Udgave nummer3
Sider (fra-til)241-8
Antal sider8
ISSN0001-690X
DOI
StatusUdgivet - mar. 2016
Eksternt udgivetJa

ID: 49813593