Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?

Goran Bjelakovic; Dimitrinka Nikolova; Christian Gluud

doi:10.1371/journal.pone.0074558

Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?

Goran Bjelakovic, Dimitrinka Nikolova, Christian Gluud

Copenhagen Trial Unit Rigshospitalet

139 Citationer (Scopus)

Abstract

Evidence shows that antioxidant supplements may increase mortality. Our aims were to assess whether different doses of beta-carotene, vitamin A, and vitamin E affect mortality in primary and secondary prevention randomized clinical trials with low risk of bias.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	9
Sider (fra-til)	e74558
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0074558
Status	Udgivet - 2013

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10.1371/journal.pone.0074558

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Citationsformater

Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? / Bjelakovic, Goran; Nikolova, Dimitrinka ; Gluud, Christian.
I: P L o S One, Bind 8, Nr. 9, 2013, s. e74558.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bjelakovic, G, Nikolova, D & Gluud, C 2013, 'Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?', P L o S One, bind 8, nr. 9, s. e74558. https://doi.org/10.1371/journal.pone.0074558

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