Messenger RNA surveillance: Neutralizing natural nonsense

Joachim Weischenfeldt; Jens Lykke-Andersen; Bo Porse

doi:10.1016/j.cub.2005.07.002

Messenger RNA surveillance: Neutralizing natural nonsense

Joachim Weischenfeldt^*, Jens Lykke-Andersen, Bo Porse

^*Corresponding author af dette arbejde

Rigshospitalet

72 Citationer (Scopus)

Abstract

Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.

Originalsprog	Engelsk
Tidsskrift	Current Biology
Vol/bind	15
Udgave nummer	14
ISSN	0960-9822
DOI	https://doi.org/10.1016/j.cub.2005.07.002
Status	Udgivet - 26 jul. 2005

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abstract = "Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.",

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AB - Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.

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Messenger RNA surveillance: Neutralizing natural nonsense

Abstract

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