Mesenchymal stromal cell phenotype is not influenced by confluence during culture expansion

Mandana Haack-Sørensen, Susanne Kofoed Hansen, Louise Hansen, Michael Gaster, Poul Hyttel, Annette Ekblond, Jens Kastrup

    16 Citationer (Scopus)

    Abstrakt

    Accumulating preclinical and clinical evidence indicates that human mesenchymal stromal cells (MSCs) are good candidates for cell therapy. For clinical applications of MSCs extensive in vitro expansion is required to obtain an adequate number of cells. It is evident that the pursuit for cell quantity must not affect quality, but it is also a fact that in vitro culture conditions affect MSC phenotype. One possible variable is the degree of cell confluence during expansion.
    OriginalsprogEngelsk
    TidsskriftStem Cell Reviews
    Vol/bind9
    Udgave nummer1
    Sider (fra-til)44-58
    Antal sider15
    ISSN1550-8943
    DOI
    StatusUdgivet - feb. 2013

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