TY - JOUR
T1 - Mental vulnerability as a risk factor for depression
T2 - A prospective cohort study in Denmark
AU - Ostergaard, Ditte
AU - Dalton, Susanne Oksbjerg
AU - Bidstrup, Pernille Envold Hansen
AU - Poulsen, Aslak Harbo
AU - Frederiksen, Kirsten
AU - Eplov, Lene Falgaard
AU - Johansen, Christoffer
AU - Mortensen, Erik Lykke
PY - 2012
Y1 - 2012
N2 - BACKGROUND: and AIM: Mental vulnerability (i.e. a tendency to experience psychosomatic symptoms, mental symptoms or interpersonal problems) is associated with various diseases. This study investigated whether mental vulnerability is associated with hospitalization for depression. METHODS: A prospective study was conducted of six cohorts from the population of Copenhagen County, Denmark, with baseline information on mental vulnerability, lifestyle, social factors and comorbidity collected in 1976, 1982-84, 1991 and 1997-98 (N = 11,862). By register-linkage information on hospital contacts for affective disorders were obtained from the Danish Psychiatric Central Register. The association between mental vulnerability and depression was examined using Kaplan-Meier plots allowing for death as competing risk and Cox proportional-hazard models adjusting for possible confounders. RESULTS: The cohort of 11,862 persons yielded a mean follow-up time of 12.3 years with 170 persons hospitalized with depression. The adjusted hazard ratio for hospitalization for depression associated with mental vulnerability was 1.23 (95% CI, 1.16-1.31) per step on the most used 12-item scale. CONCLUSIONS: Mental vulnerability may be a risk factor for depression. Early identification and treatment of depression are essential for preventing chronic depression, reduced social functioning and disability. Psychiatric interviews should be used to evaluate whether the criteria for depression are fulfilled, but it may furthermore be relevant to identify persons who may be at risk of developing depression in the long term. The possibility of using, for example, the mental vulnerability scale for such purpose should be further investigated.
AB - BACKGROUND: and AIM: Mental vulnerability (i.e. a tendency to experience psychosomatic symptoms, mental symptoms or interpersonal problems) is associated with various diseases. This study investigated whether mental vulnerability is associated with hospitalization for depression. METHODS: A prospective study was conducted of six cohorts from the population of Copenhagen County, Denmark, with baseline information on mental vulnerability, lifestyle, social factors and comorbidity collected in 1976, 1982-84, 1991 and 1997-98 (N = 11,862). By register-linkage information on hospital contacts for affective disorders were obtained from the Danish Psychiatric Central Register. The association between mental vulnerability and depression was examined using Kaplan-Meier plots allowing for death as competing risk and Cox proportional-hazard models adjusting for possible confounders. RESULTS: The cohort of 11,862 persons yielded a mean follow-up time of 12.3 years with 170 persons hospitalized with depression. The adjusted hazard ratio for hospitalization for depression associated with mental vulnerability was 1.23 (95% CI, 1.16-1.31) per step on the most used 12-item scale. CONCLUSIONS: Mental vulnerability may be a risk factor for depression. Early identification and treatment of depression are essential for preventing chronic depression, reduced social functioning and disability. Psychiatric interviews should be used to evaluate whether the criteria for depression are fulfilled, but it may furthermore be relevant to identify persons who may be at risk of developing depression in the long term. The possibility of using, for example, the mental vulnerability scale for such purpose should be further investigated.
U2 - 10.1177/0020764010396409
DO - 10.1177/0020764010396409
M3 - Journal article
C2 - 21441278
SN - 1741-2854
VL - 58
SP - 302
EP - 314
JO - The International journal of social psychiatry
JF - The International journal of social psychiatry
IS - 3
ER -