TY - JOUR
T1 - Mental health among patients with non-Hodgkin lymphoma
T2 - A Danish nationwide study of psychotropic drug use in 8750 patients and 43 750 matched comparators
AU - Øvlisen, Andreas Kiesbye
AU - Jakobsen, Lasse Hjort
AU - Kragholm, Kristian Hay
AU - Nielsen, René Ernst
AU - de Nully Brown, Peter
AU - Dahl-Sørensen, Rasmus Bo
AU - Frederiksen, Henrik
AU - Mannering, Nikolaj
AU - Josefsson, Pär Lars
AU - Ludvigsen Al-Mashhadi, Ahmed
AU - Jørgensen, Judit Mészáros
AU - Dessau-Arp, Andriette
AU - Clausen, Michael Roost
AU - Pedersen, Robert Schou
AU - Torp-Pedersen, Christian
AU - Severinsen, Marianne Tang
AU - El-Galaly, Tarec Christoffer
N1 - © 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. Non-Hodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDs-antidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide population-based registries to investigate the cumulative risk of PD use in NHL patients compared to a sex- and age-matched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional self-harm or completed suicide were explored. In total, 8750 NHL patients and 43 750 matched comparators were included (median age 68; male:female ratio 1.6). Median follow-up was 7.1 years. Two-year cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p < .01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5 years into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher two-year risk of suicide/intentional self-harm (0.3%) as compared to the matched comparators (0.2%, p = .01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard follow-up of NHL patients.
AB - Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. Non-Hodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDs-antidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide population-based registries to investigate the cumulative risk of PD use in NHL patients compared to a sex- and age-matched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional self-harm or completed suicide were explored. In total, 8750 NHL patients and 43 750 matched comparators were included (median age 68; male:female ratio 1.6). Median follow-up was 7.1 years. Two-year cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p < .01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5 years into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher two-year risk of suicide/intentional self-harm (0.3%) as compared to the matched comparators (0.2%, p = .01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard follow-up of NHL patients.
KW - Aged
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Lymphoma, Non-Hodgkin/complications
KW - Male
KW - Mental Health
KW - Prospective Studies
KW - Psychotropic Drugs/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=85127233312&partnerID=8YFLogxK
U2 - 10.1002/ajh.26538
DO - 10.1002/ajh.26538
M3 - Journal article
C2 - 35298039
SN - 0361-8609
VL - 97
SP - 749
EP - 761
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 6
ER -