Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution and intraretinal connectivity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Costs of subcutaneous and intravenous administration of trastuzumab for patients with HER2-positive breast cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas - a comparative study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The molecular profile of mucosal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Monocular and binocular end-points after epiretinal membrane surgery and their correlation to patient-reported outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex and sleep/wake cycles. The different functions seem to be associated to different subtypes of melanopsin cells. In rodents, subtype classification has associated subtypes to function. In primate and human retina such classification has so far, not been applied. In the present study using antibodies against N- and C-terminal parts of human melanopsin, confocal microscopy and 3D reconstruction of melanopsin immunoreactive (-ir) RGCs, we applied the criteria used in mouse on human melanopsin-ir RGCs. We identified M1, displaced M1, M2 and M4 cells. We found two other subtypes of melanopsin-ir RGCs, which were named "gigantic M1 (GM1)" and "gigantic displaced M1 (GDM1)". Few M3 cells and no M5 subtypes were labelled. Total cell counts from one male and one female retina revealed that the human retina contains 7283±237 melanopsin-ir (0.63-0.75% of the total number of RGCs). The melanopsin subtypes were unevenly distributed. Most significant was the highest density of M4 cells in the nasal retina. We identified input to the melanopsin-ir RGCs from AII amacrine cells and directly from rod bipolar cells via ribbon synapses in the innermost ON layer of the inner plexiform layer (IPL) and from dopaminergic amacrine cells and GABAergic processes in the outermost OFF layer of the IPL. The study characterizes a heterogenic population of human melanopsin-ir RGCs, which most likely are involved in different functions. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftThe Journal of comparative neurology
Vol/bind525
Udgave nummer8
Sider (fra-til)1934-1961
ISSN0021-9967
DOI
StatusUdgivet - 3 feb. 2017

ID: 49834170