Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia

Ingrid Glimelius; Geffen Kleinstern; Dennis P Robinson; Larry Mansouri; Klaus Rostgaard; Henrik Hjalgrim; Carsten Utoft Niemann; Mattias Mattsson; Kari G Rabe; Paul J Hampel; Sameer A Parikh; Richard Rosenquist; James R Cerhan; Susan L Slager; Karin E Smedby

doi:10.1002/jha2.1000

Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia

Ingrid Glimelius^*, Geffen Kleinstern^*, Dennis P Robinson, Larry Mansouri, Klaus Rostgaard, Henrik Hjalgrim, Carsten Utoft Niemann, Mattias Mattsson, Kari G Rabe, Paul J Hampel, Sameer A Parikh, Richard Rosenquist, James R Cerhan, Susan L Slager, Karin E Smedby

^*Corresponding author af dette arbejde

Afdeling for Blodsygdomme

Abstract

BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease. Whereas some patients have an indolent disease, others experience an aggressive course and early death. Our aim was to investigate if modifiable and non-modifiable medical history and lifestyle factors prior to diagnosis had an impact on the natural course of the disease.

METHOD: In 1154 CLL patients, we assessed if the weight, physical activity, smoking, and alcohol consumption or non-modifiable characteristics including family history of lymphoid malignancy and medical history were associated with time-to-first-treatment (TTFT) and adjusted all results for the CLL-International Prognostic Index (CLL-IPI).

RESULTS: TTFT was shorter for patients with high/very high-risk CLL-IPI than those with low/intermediate risk CLL-IPI. In the adjusted analysis we did not find additional impact on TTFT besides CLL-IPI from any environmental characteristics assessed.

CONCLUSIONS: We found limited impact of environmental factors on the natural course of CLL (measured as the TTFT in treatment naïve patients) providing valuable knowledge, and potential relief, to share with patients at the time of diagnosis.

Originalsprog	Engelsk
Tidsskrift	EJHaem
Vol/bind	5
Udgave nummer	5
Sider (fra-til)	998-1004
Antal sider	7
ISSN	2688-6146
DOI	https://doi.org/10.1002/jha2.1000
Status	Udgivet - okt. 2024

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10.1002/jha2.1000Licens: CC BY-NC

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Glimelius, I., Kleinstern, G., Robinson, D. P., Mansouri, L., Rostgaard, K., Hjalgrim, H., Niemann, C. U., Mattsson, M., Rabe, K. G., Hampel, P. J., Parikh, S. A., Rosenquist, R., Cerhan, J. R., Slager, S. L., & Smedby, K. E. (2024). Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia. EJHaem, 5(5), 998-1004. https://doi.org/10.1002/jha2.1000

Glimelius, I, Kleinstern, G, Robinson, DP, Mansouri, L, Rostgaard, K, Hjalgrim, H , Niemann, CU, Mattsson, M, Rabe, KG, Hampel, PJ, Parikh, SA, Rosenquist, R, Cerhan, JR, Slager, SL & Smedby, KE 2024, 'Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia', EJHaem, bind 5, nr. 5, s. 998-1004. https://doi.org/10.1002/jha2.1000

@article{b17daf639e4f4a25ac1d6401b6367bf6,

title = "Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia",

abstract = "BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease. Whereas some patients have an indolent disease, others experience an aggressive course and early death. Our aim was to investigate if modifiable and non-modifiable medical history and lifestyle factors prior to diagnosis had an impact on the natural course of the disease.METHOD: In 1154 CLL patients, we assessed if the weight, physical activity, smoking, and alcohol consumption or non-modifiable characteristics including family history of lymphoid malignancy and medical history were associated with time-to-first-treatment (TTFT) and adjusted all results for the CLL-International Prognostic Index (CLL-IPI).RESULTS: TTFT was shorter for patients with high/very high-risk CLL-IPI than those with low/intermediate risk CLL-IPI. In the adjusted analysis we did not find additional impact on TTFT besides CLL-IPI from any environmental characteristics assessed.CONCLUSIONS: We found limited impact of environmental factors on the natural course of CLL (measured as the TTFT in treatment na{\"i}ve patients) providing valuable knowledge, and potential relief, to share with patients at the time of diagnosis.",

author = "Ingrid Glimelius and Geffen Kleinstern and Robinson, {Dennis P} and Larry Mansouri and Klaus Rostgaard and Henrik Hjalgrim and Niemann, {Carsten Utoft} and Mattias Mattsson and Rabe, {Kari G} and Hampel, {Paul J} and Parikh, {Sameer A} and Richard Rosenquist and Cerhan, {James R} and Slager, {Susan L} and Smedby, {Karin E}",

note = "{\textcopyright} 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2024",

month = oct,

doi = "10.1002/jha2.1000",

language = "English",

volume = "5",

pages = "998--1004",

journal = "EJHaem",

issn = "2688-6146",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia

AU - Glimelius, Ingrid

AU - Kleinstern, Geffen

AU - Robinson, Dennis P

AU - Mansouri, Larry

AU - Rostgaard, Klaus

AU - Hjalgrim, Henrik

AU - Niemann, Carsten Utoft

AU - Mattsson, Mattias

AU - Rabe, Kari G

AU - Hampel, Paul J

AU - Parikh, Sameer A

AU - Rosenquist, Richard

AU - Cerhan, James R

AU - Slager, Susan L

AU - Smedby, Karin E

PY - 2024/10

Y1 - 2024/10

N2 - BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease. Whereas some patients have an indolent disease, others experience an aggressive course and early death. Our aim was to investigate if modifiable and non-modifiable medical history and lifestyle factors prior to diagnosis had an impact on the natural course of the disease.METHOD: In 1154 CLL patients, we assessed if the weight, physical activity, smoking, and alcohol consumption or non-modifiable characteristics including family history of lymphoid malignancy and medical history were associated with time-to-first-treatment (TTFT) and adjusted all results for the CLL-International Prognostic Index (CLL-IPI).RESULTS: TTFT was shorter for patients with high/very high-risk CLL-IPI than those with low/intermediate risk CLL-IPI. In the adjusted analysis we did not find additional impact on TTFT besides CLL-IPI from any environmental characteristics assessed.CONCLUSIONS: We found limited impact of environmental factors on the natural course of CLL (measured as the TTFT in treatment naïve patients) providing valuable knowledge, and potential relief, to share with patients at the time of diagnosis.

AB - BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease. Whereas some patients have an indolent disease, others experience an aggressive course and early death. Our aim was to investigate if modifiable and non-modifiable medical history and lifestyle factors prior to diagnosis had an impact on the natural course of the disease.METHOD: In 1154 CLL patients, we assessed if the weight, physical activity, smoking, and alcohol consumption or non-modifiable characteristics including family history of lymphoid malignancy and medical history were associated with time-to-first-treatment (TTFT) and adjusted all results for the CLL-International Prognostic Index (CLL-IPI).RESULTS: TTFT was shorter for patients with high/very high-risk CLL-IPI than those with low/intermediate risk CLL-IPI. In the adjusted analysis we did not find additional impact on TTFT besides CLL-IPI from any environmental characteristics assessed.CONCLUSIONS: We found limited impact of environmental factors on the natural course of CLL (measured as the TTFT in treatment naïve patients) providing valuable knowledge, and potential relief, to share with patients at the time of diagnosis.

U2 - 10.1002/jha2.1000

DO - 10.1002/jha2.1000

M3 - Journal article

C2 - 39415908

SN - 2688-6146

VL - 5

SP - 998

EP - 1004

JO - EJHaem

JF - EJHaem

IS - 5

ER -

Medical history and lifestyle factors have limited impact on time-to-first-treatment in patients with chronic lymphocytic leukemia

Abstract

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