@article{6472e335bae549e4a207064963353acc,
title = "Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort",
abstract = "Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).",
keywords = "Cell Line, Tumor, Chromosomes, Human, Pair 2, Chromosomes, Human, Pair 20, Cohort Studies, Colorectal Neoplasms, DNA Topoisomerases, Type I, Female, Gene Dosage, Humans, In Situ Hybridization, Fluorescence, Male, Middle Aged, Neoplasm Staging, Prognosis",
author = "Smith, {David Hersi} and Christensen, {Ib Jarle} and Jensen, {Niels Frank} and Markussen, {Thomas Bo} and R{\o}mer, {Maria Unni Koefoed} and Nyg{\aa}rd, {Sune Boris} and Sven M{\"u}ller and Nielsen, {Hans J{\o}rgen} and Br{\"u}nner, {Nils Aage} and Nielsen, {Kirsten Vang}",
year = "2013",
doi = "10.1371/journal.pone.0060613",
language = "English",
volume = "8",
pages = "e60613",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",
}