Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes

Andrea Mari, Jonatan I Bagger, Ele Ferrannini, Jens Juul Holst, Filip K Knop, Tina Vilsbøll

    31 Citationer (Scopus)

    Abstract

    The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI). The ß-cell response was evaluated using a model embedding a dose-response (slope=glucose sensitivity), an early response (rate sensitivity), and potentiation (time-related secretion increase). The incretin effect, as OGTT/IIGI ratio, was calculated for each parameter. In NGT, the incretin effect on total secretion increased with dose (1.3 ± 0.1, 1.7 ± 0.2, 2.2 ± 0.2 fold of IIGI, P
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind8
    Udgave nummer9
    Sider (fra-til)e73154
    ISSN1932-6203
    DOI
    StatusUdgivet - 2013

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