TY - JOUR
T1 - Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes
AU - Mari, Andrea
AU - Bagger, Jonatan I
AU - Ferrannini, Ele
AU - Holst, Jens Juul
AU - Knop, Filip K
AU - Vilsbøll, Tina
PY - 2013
Y1 - 2013
N2 - The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI). The ß-cell response was evaluated using a model embedding a dose-response (slope=glucose sensitivity), an early response (rate sensitivity), and potentiation (time-related secretion increase). The incretin effect, as OGTT/IIGI ratio, was calculated for each parameter. In NGT, the incretin effect on total secretion increased with dose (1.3 ± 0.1, 1.7 ± 0.2, 2.2 ± 0.2 fold of IIGI, P
AB - The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI). The ß-cell response was evaluated using a model embedding a dose-response (slope=glucose sensitivity), an early response (rate sensitivity), and potentiation (time-related secretion increase). The incretin effect, as OGTT/IIGI ratio, was calculated for each parameter. In NGT, the incretin effect on total secretion increased with dose (1.3 ± 0.1, 1.7 ± 0.2, 2.2 ± 0.2 fold of IIGI, P
U2 - 10.1371/journal.pone.0073154
DO - 10.1371/journal.pone.0073154
M3 - Journal article
C2 - 24019903
VL - 8
SP - e73154
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 9
ER -