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Mechanisms of migraine as a chronic evolutive condition

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  4. Functional connectivity studies in migraine: what have we learned?

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  5. C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

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  1. Hyperpolarization through ATP-sensitive potassium channels; relevance to migraine pathology

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  2. Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache

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  3. CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles

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  4. Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an "evolutive" chronic condition. Considerable progress has been made in elucidating the pathophysiological mechanisms of migraine, associated genetic factors that may influence susceptibility to the disease, and functional and anatomical changes during the progression of a migraine attack or the transformation of episodic to chronic migraine. Migraine is a life span neurological disorder that follows an evolutive age-dependent change in its prevalence and even clinical presentations. As a disorder, migraine involves recurrent intense head pain and associated unpleasant symptoms. Migraine attacks evolve over different phases with specific neural mechanisms and symptoms being involved during each phase. In some patients, migraine can be transformed into a chronic form with daily or almost daily headaches. The mechanisms behind this evolutive process remain unknown, but genetic and epigenetic factors, inflammatory processes and central sensitization may play an important role.

OriginalsprogEngelsk
TidsskriftThe Journal of Headache and Pain Online
Vol/bind20
Udgave nummer1
Sider (fra-til)117
ISSN1129-2377
DOI
StatusUdgivet - 23 dec. 2019
Eksternt udgivetJa

ID: 59203441