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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mechanism-Based Modeling of Gastric Emptying Rate and Gallbladder Emptying in Response to Caloric Intake

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Bile acids released postprandially modify the rate and extent of absorption of lipophilic compounds. The present study aimed to predict gastric emptying (GE) rate and gallbladder emptying (GBE) patterns in response to caloric intake. A mechanism-based model for GE, cholecystokinin plasma concentrations, and GBE was developed on data from 33 patients with type 2 diabetes and 33 matched nondiabetic individuals who were administered various test drinks. A feedback action of the caloric content entering the proximal small intestine was identified for the rate of GE. The cholecystokinin concentrations were not predictive of GBE, and an alternative model linking the nutrients amount in the upper intestine to GBE was preferred. Relative to fats, the potency on GBE was 68% for proteins and 2.3% for carbohydrates. The model predictions were robust across a broad range of nutritional content and may potentially be used to predict postprandial changes in drug absorption.

OriginalsprogEngelsk
TidsskriftCPT: pharmacometrics & systems pharmacology
Vol/bind5
Udgave nummer12
Sider (fra-til)692-700
Antal sider9
ISSN2163-8306
DOI
StatusUdgivet - dec. 2016

ID: 49591307