Measurement of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA and human urine by high performance liquid chromatography-electrospray tandem mass spectrometry

Keyphrases

• Human Urine 100%
• 8-oxoguanine 100%
• High-performance Liquid Chromatography 100%
• 2′-deoxyadenosine 100%
• Liquid Chromatography-electrospray Tandem Mass Spectrometry 100%
• Limit of Detection 33%
• Urine Samples 33%
• High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) 33%
• Highly Sensitive 16%
• Adenosine 16%
• Oxidative DNA Damage 16%
• Guanosine 16%
• Centrifugation 16%
• 2′-Deoxyguanosine 16%
• Circulating Tumor DNA (ctDNA) 16%
• Chromatographic Column 16%
• Oxidized nucleotides 16%
• No Sample Preparation 16%
• Artifact Formation 16%
• DNA Level 16%
• Minimal Losses 16%

Chemistry

• Deoxyribonucleic Acid 100%
• Tandem Mass Spectrometry 100%
• High-Pressure Liquid Chromatography 100%
• Electrospray 100%
• High Performance Liquid Chromatography 75%
• Liquid Chromatography Tandem Mass Spectrometry 50%
• Buffer Solution 25%
• Chromatography Column 25%
• Centrifugation 25%
• formation 25%
• Guanosine 25%
• Nucleotide 25%
• Adenosine 25%

Pharmacology, Toxicology and Pharmaceutical Science

• High Performance Liquid Chromatography 100%
• 8 Hydroxydeoxyguanosine 100%
• Electrospray Ionization 100%
• Deoxyadenosine 100%
• Adenosine 16%
• Buffer 16%
• Guanosine 16%
• Deoxyguanosine 16%