Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle

John A Hawley, Carsten Lundby, James D Cotter, Louise M Burke

    129 Citationer (Scopus)

    Abstract

    The application of molecular techniques to exercise biology has provided novel insight into the complexity and breadth of intracellular signaling networks involved in response to endurance-based exercise. Here we discuss several strategies that have high uptake by athletes and, on mechanistic grounds, have the potential to promote cellular adaptation to endurance training in skeletal muscle. Such approaches are based on the underlying premise that imposing a greater metabolic load and provoking extreme perturbations in cellular homeostasis will augment acute exercise responses that, when repeated over months and years, will amplify training adaptation.

    OriginalsprogEngelsk
    TidsskriftCell Metabolism
    Vol/bind27
    Udgave nummer5
    Sider (fra-til)962-976
    Antal sider15
    ISSN1550-4131
    DOI
    StatusUdgivet - 1 maj 2018

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