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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mature lymphoid malignancies: origin, stem cells, and chronicity

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Vis graf over relationer

The chronic behavior of mature lymphoid malignancies, with relapses occurring years apart in many patients, has until recently been unexplained. Patterns of relapse also differ vastly between disease entities, with some being highly curable by chemotherapy whereas others are destined to reemerge after treatment. Lately, the use of next-generation sequencing techniques has revealed essential information on the clonal evolution of lymphoid malignancies. Also, experimental xenograft transplantation point to the possible existence of an ancestral (stem) cell. Such a malignant lymphoid stem cell population could potentially evade current therapies and be the cause of chronicity and death in lymphoma patients; however, the evidence is divergent across disease entities and between studies. In this review we present an overview of genetic studies, case reports, and experimental evidence of the source of mature lymphoid malignancy and discuss the perspectives.

OriginalsprogEngelsk
TidsskriftBlood advances
Vol/bind1
Udgave nummer25
Sider (fra-til)2444-2455
Antal sider12
ISSN2473-9529
DOI
StatusUdgivet - 28 nov. 2017

ID: 52709902