Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Simvastatin improves mitochondrial respiration in peripheral blood cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Discrete finger sequences are widely represented in human striatum

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Author Correction: Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk of neurological disorders in patients with European Lyme neuroborreliosis. A nationwide population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Defibrillators for prevention from sudden cardiac death: is it that easy?-Authors' reply

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular matrix, is cleaved by matrix metalloproteinases (MMPs) generating the neo-epitope C1M. We investigated the association between serum-C1M and AMI and evaluated whether C1M is a prognostic marker for outcome following AMI. This study is based on The Prospective Epidemiological Risk Factor (PERF) Study including postmenopausal women. 316 out of 5,450 women developed AMI within the follow-up period (14 years, median). A multivariate Cox analysis assessed association between serum-C1M and AMI, and re-infaction or death subsequent to AMI. The risk of AMI increased by 18% (p = 0.03) when serum-C1M was doubled and women in the highest quartile had a 33% increased risk compared to those in the low quartiles (p = 0.025). Serum-C1M was, however not related to reinfarction or death subsequent to AMI. In this study C1M was be an independent risk factor for AMI. Measuring MMP degraded type I collagen could be useful for prediction of increased risk of AMI if replicated in other cohorts.

OriginalsprogEngelsk
TidsskriftScientific Reports
Vol/bind8
Udgave nummer1
Sider (fra-til)5371
ISSN2045-2322
DOI
StatusUdgivet - 29 mar. 2018

ID: 54875460