Maternal antibiotic use and risk of asthma in offspring--Authors' reply

Hans Bisgaard; Jakob Stokholm; Astrid Sevelsted; Klaus Bønnelykke

doi:10.1016/S2213-2600(14)70221-8

Maternal antibiotic use and risk of asthma in offspring--Authors' reply

Hans Bisgaard, Jakob Stokholm, Astrid Sevelsted, Klaus Bønnelykke

Allergi, Hud- og Kønssygdomme

4 Citationer (Scopus)

Abstract

We thank Martin J Blaser and Maria Bello for their interest in our study.1 Our original discovery of an association between use of antibiotics in pregnancy and an offspring's risk of asthma was replicated in the COPSAC2000 birth cohort and another Danish birth cohort, as well as in national registries.2,3 We interpreted this association between use of antibiotics in pregnancy and the child's risk of asthma as one that was mediated through changes in the microbiome. In our study we aimed to test this hypothesis by investigating the temporal associations between maternal antibiotics and childhood asthma.

Originalsprog	Engelsk
Tidsskrift	The Lancet Respiratory Medicine
Vol/bind	2
Udgave nummer	10
Sider (fra-til)	e17
Antal sider	1
ISSN	2213-2600
DOI	https://doi.org/10.1016/S2213-2600(14)70221-8
Status	Udgivet - okt. 2014

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10.1016/S2213-2600(14)70221-8

Citationsformater

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abstract = "We thank Martin J Blaser and Maria Bello for their interest in our study.1 Our original discovery of an association between use of antibiotics in pregnancy and an offspring's risk of asthma was replicated in the COPSAC2000 birth cohort and another Danish birth cohort, as well as in national registries.2,3 We interpreted this association between use of antibiotics in pregnancy and the child's risk of asthma as one that was mediated through changes in the microbiome. In our study we aimed to test this hypothesis by investigating the temporal associations between maternal antibiotics and childhood asthma.",

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N2 - We thank Martin J Blaser and Maria Bello for their interest in our study.1 Our original discovery of an association between use of antibiotics in pregnancy and an offspring's risk of asthma was replicated in the COPSAC2000 birth cohort and another Danish birth cohort, as well as in national registries.2,3 We interpreted this association between use of antibiotics in pregnancy and the child's risk of asthma as one that was mediated through changes in the microbiome. In our study we aimed to test this hypothesis by investigating the temporal associations between maternal antibiotics and childhood asthma.

AB - We thank Martin J Blaser and Maria Bello for their interest in our study.1 Our original discovery of an association between use of antibiotics in pregnancy and an offspring's risk of asthma was replicated in the COPSAC2000 birth cohort and another Danish birth cohort, as well as in national registries.2,3 We interpreted this association between use of antibiotics in pregnancy and the child's risk of asthma as one that was mediated through changes in the microbiome. In our study we aimed to test this hypothesis by investigating the temporal associations between maternal antibiotics and childhood asthma.

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Maternal antibiotic use and risk of asthma in offspring--Authors' reply

Abstract

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