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Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy

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Harvard

Sabers, A, Battino, D, Bonizzoni, E, Craig, J, Lindhout, D, Perucca, E, Thomas, SV, Tomson, T & Vajda, F 2017, 'Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy', Epilepsy Research, bind 137, s. 159-162. https://doi.org/10.1016/j.eplepsyres.2017.05.013

APA

Sabers, A., Battino, D., Bonizzoni, E., Craig, J., Lindhout, D., Perucca, E., Thomas, S. V., Tomson, T., & Vajda, F. (2017). Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy. Epilepsy Research, 137, 159-162. https://doi.org/10.1016/j.eplepsyres.2017.05.013

CBE

Sabers A, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Thomas SV, Tomson T, Vajda F. 2017. Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy. Epilepsy Research. 137:159-162. https://doi.org/10.1016/j.eplepsyres.2017.05.013

MLA

Vancouver

Author

Sabers, Anne ; Battino, Dina ; Bonizzoni, Erminio ; Craig, John ; Lindhout, Dick ; Perucca, Emilio ; Thomas, Sanjeev V ; Tomson, Torbjörn ; Vajda, Frank. / Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy. I: Epilepsy Research. 2017 ; Bind 137. s. 159-162.

Bibtex

@article{8fa06689022947c2abeca25d600f497e,
title = "Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy",
abstract = "OBJECTIVE: To access the effect of vagus nerve stimulation (VNS) on the outcome of pregnancy.METHODS: We used the International Registry of Antiepileptic Drugs and Pregnancy (EURAP) and its network to search for women receiving adjunctive VNS during pregnancy. Data on maternal and fetal outcomes were extracted from the registry databases and outcomes were evaluated.RESULTS: Twenty-six pregnancies were identified in 25 women. All women were exposed to a relative high VNS stimulation level (mean duty cycle 18%, range 5%-51%). Most women had seizures during pregnancy and almost 70% were on antiepileptic drug (AED) polytherapy. The proportion of women with obstetrical interventions was 53.9% (95% confidence interval [CI] 33.4%-73.4%) which was higher compared to the EURAP average (48.2%; 95% CI 47.2%-49.1%). One infant (3.9%; 95% CI 0.1%-19.6%) was born with a major malformation (unilateral congenital glaucoma), which is within the range expected among offspring of AED-treated women.CONCLUSION: Although the present series of VNS-exposed pregnancies is the largest reported to date, the sample size is insufficient to draw any firm conclusions on the safety of VNS in pregnancy but the findings suggest an increased rate of obstetrical interventions, and no clear signal of VNS-related teratogenicity.",
keywords = "Journal Article",
author = "Anne Sabers and Dina Battino and Erminio Bonizzoni and John Craig and Dick Lindhout and Emilio Perucca and Thomas, {Sanjeev V} and Torbj{\"o}rn Tomson and Frank Vajda",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
doi = "10.1016/j.eplepsyres.2017.05.013",
language = "English",
volume = "137",
pages = "159--162",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy

AU - Sabers, Anne

AU - Battino, Dina

AU - Bonizzoni, Erminio

AU - Craig, John

AU - Lindhout, Dick

AU - Perucca, Emilio

AU - Thomas, Sanjeev V

AU - Tomson, Torbjörn

AU - Vajda, Frank

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: To access the effect of vagus nerve stimulation (VNS) on the outcome of pregnancy.METHODS: We used the International Registry of Antiepileptic Drugs and Pregnancy (EURAP) and its network to search for women receiving adjunctive VNS during pregnancy. Data on maternal and fetal outcomes were extracted from the registry databases and outcomes were evaluated.RESULTS: Twenty-six pregnancies were identified in 25 women. All women were exposed to a relative high VNS stimulation level (mean duty cycle 18%, range 5%-51%). Most women had seizures during pregnancy and almost 70% were on antiepileptic drug (AED) polytherapy. The proportion of women with obstetrical interventions was 53.9% (95% confidence interval [CI] 33.4%-73.4%) which was higher compared to the EURAP average (48.2%; 95% CI 47.2%-49.1%). One infant (3.9%; 95% CI 0.1%-19.6%) was born with a major malformation (unilateral congenital glaucoma), which is within the range expected among offspring of AED-treated women.CONCLUSION: Although the present series of VNS-exposed pregnancies is the largest reported to date, the sample size is insufficient to draw any firm conclusions on the safety of VNS in pregnancy but the findings suggest an increased rate of obstetrical interventions, and no clear signal of VNS-related teratogenicity.

AB - OBJECTIVE: To access the effect of vagus nerve stimulation (VNS) on the outcome of pregnancy.METHODS: We used the International Registry of Antiepileptic Drugs and Pregnancy (EURAP) and its network to search for women receiving adjunctive VNS during pregnancy. Data on maternal and fetal outcomes were extracted from the registry databases and outcomes were evaluated.RESULTS: Twenty-six pregnancies were identified in 25 women. All women were exposed to a relative high VNS stimulation level (mean duty cycle 18%, range 5%-51%). Most women had seizures during pregnancy and almost 70% were on antiepileptic drug (AED) polytherapy. The proportion of women with obstetrical interventions was 53.9% (95% confidence interval [CI] 33.4%-73.4%) which was higher compared to the EURAP average (48.2%; 95% CI 47.2%-49.1%). One infant (3.9%; 95% CI 0.1%-19.6%) was born with a major malformation (unilateral congenital glaucoma), which is within the range expected among offspring of AED-treated women.CONCLUSION: Although the present series of VNS-exposed pregnancies is the largest reported to date, the sample size is insufficient to draw any firm conclusions on the safety of VNS in pregnancy but the findings suggest an increased rate of obstetrical interventions, and no clear signal of VNS-related teratogenicity.

KW - Journal Article

U2 - 10.1016/j.eplepsyres.2017.05.013

DO - 10.1016/j.eplepsyres.2017.05.013

M3 - Journal article

C2 - 29054513

VL - 137

SP - 159

EP - 162

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -

ID: 52426126