TY - JOUR
T1 - Markers of inflammation and hemodynamic measurements in obesity: Copenhagen City Heart Study
AU - Asferg, Camilla Lundegaard
AU - Jensen, Jan S
AU - Marott, Jacob Louis
AU - Appleyard, Merete
AU - Møgelvang, Rasmus
AU - Jensen, Gorm B
AU - Jeppesen, Jørgen
N1 - Markers of Inflammation and Hemodynamic Measurements in Obesity: Copenhagen City Heart Study
Camilla Asferg1⇓, Jan S. Jensen2,3, Jacob L. Marott4, Merete Appleyard4, Rasmus Møgelvang2, Gorm B. Jensen3,5 and Jørgen Jeppesen3,6
- Author Affiliations
1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Glostrup, Denmark
2Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark
3Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
4Copenhagen City Heart Study, Copenhagen University Hospital, Copenhagen, Denmark
5Department of Cardiology, Copenhagen University Hospital, Hvidovre, Denmark
6Department of Medicine, Copenhagen University Hospital, Glostrup, Denmark
Keywords: Adult; Aged; Aged, 80 and over; Ankle Brachial Index; Blood Pressure; Body Mass Index; C-Reactive Protein; Denmark; Female; Fibrinogen; Hemodynamics; Humans; Hypertension; Inflammation; Male; Middle Aged; Obesity
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Low-grade chronic inflammation has been proposed to play a major role in the pathogenesis of hypertension. Low-grade chronic inflammation is also closely associated with obesity, an established causative factor in the development of hypertension. The purpose of this study was to investigate the relationship between two markers of inflammation, C-reactive protein (CRP) and fibrinogen, and blood pressure (BP) and other hemodynamic variables in obese subjects. METHODS: From a large cardiovascular study based in the general population, we selected subjects with a body mass index (BMI) > or =30 kg/m2, free of major cardiovascular diseases, not taking BP-lowering or lipid-lowering drugs (n = 487; women = 51.1%; median (5th to 95th percentile) age = 62 years (36-80)). The cardiovascular study included measurements of traditional and new risk factors, including ankle brachial BP index, a measure of subclinical atherosclerosis. CRP was determined by a high-sensitive assay. RESULTS: In partial Spearman rank correlation analysis, adjusted for age and sex, we found no significant relationships between either CRP or fibrinogen and systolic BP, diastolic BP, pulse pressure, or ankle brachial index (rho: -0.057 to 0.068; P > 0.13). However, fibrinogen and CRP were found to be significantly related to heart rate (rho: 0.127-0.169; P < 0.01). CONCLUSIONS: In this study of generally healthy obese subjects from the general population, we found no significant relationships between markers of inflammation and systolic BP or diastolic BP, showing that obese subjects with higher levels of inflammatory markers do not have higher BP levels than their obese counterparts with lower levels of inflammatory markers.
AB - BACKGROUND: Low-grade chronic inflammation has been proposed to play a major role in the pathogenesis of hypertension. Low-grade chronic inflammation is also closely associated with obesity, an established causative factor in the development of hypertension. The purpose of this study was to investigate the relationship between two markers of inflammation, C-reactive protein (CRP) and fibrinogen, and blood pressure (BP) and other hemodynamic variables in obese subjects. METHODS: From a large cardiovascular study based in the general population, we selected subjects with a body mass index (BMI) > or =30 kg/m2, free of major cardiovascular diseases, not taking BP-lowering or lipid-lowering drugs (n = 487; women = 51.1%; median (5th to 95th percentile) age = 62 years (36-80)). The cardiovascular study included measurements of traditional and new risk factors, including ankle brachial BP index, a measure of subclinical atherosclerosis. CRP was determined by a high-sensitive assay. RESULTS: In partial Spearman rank correlation analysis, adjusted for age and sex, we found no significant relationships between either CRP or fibrinogen and systolic BP, diastolic BP, pulse pressure, or ankle brachial index (rho: -0.057 to 0.068; P > 0.13). However, fibrinogen and CRP were found to be significantly related to heart rate (rho: 0.127-0.169; P < 0.01). CONCLUSIONS: In this study of generally healthy obese subjects from the general population, we found no significant relationships between markers of inflammation and systolic BP or diastolic BP, showing that obese subjects with higher levels of inflammatory markers do not have higher BP levels than their obese counterparts with lower levels of inflammatory markers.
U2 - 10.1038/ajh.2009.1
DO - 10.1038/ajh.2009.1
M3 - Journal article
C2 - 19229196
SN - 1879-1905
SN - 1941-7225
VL - 22
SP - 451
EP - 456
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 4
ER -