Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

M H Olsen, M K Christensen, K Wachtell, Christian Tuxen, E Fossum, L E Bang, N Wiinberg, R B Devereux, S E Kjeldsen, Per Hildebrandt, H Dige-Petersen, J Rokkedal, H Ibsen

33 Citationer (Scopus)

Abstract

Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P
OriginalsprogEngelsk
TidsskriftJournal of Human Hypertension
Vol/bind19
Udgave nummer4
Sider (fra-til)301-7
Antal sider7
ISSN0950-9240
DOI
StatusUdgivet - 2005

Fingeraftryk

Dyk ned i forskningsemnerne om 'Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy'. Sammen danner de et unikt fingeraftryk.

Citationsformater