Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

M H Olsen; M K Christensen; K Wachtell; Christian Tuxen; E Fossum; L E Bang; N Wiinberg; R B Devereux; S E Kjeldsen; Per Hildebrandt; H Dige-Petersen; J Rokkedal; H Ibsen

doi:10.1038/sj.jhh.1001819

Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

M H Olsen, M K Christensen, K Wachtell, Christian Tuxen, E Fossum, L E Bang, N Wiinberg, R B Devereux, S E Kjeldsen, Per Hildebrandt, H Dige-Petersen, J Rokkedal, H Ibsen

31 Citationer (Scopus)

Abstrakt

Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P

Originalsprog	Engelsk
Tidsskrift	Journal of Human Hypertension
Vol/bind	19
Udgave nummer	4
Sider (fra-til)	301-7
Antal sider	7
ISSN	0950-9240
DOI	https://doi.org/10.1038/sj.jhh.1001819
Status	Udgivet - 2005

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10.1038/sj.jhh.1001819

Citationsformater

Olsen, M. H., Christensen, M. K., Wachtell, K., Tuxen, C., Fossum, E., Bang, L. E., Wiinberg, N., Devereux, R. B., Kjeldsen, S. E., Hildebrandt, P., Dige-Petersen, H., Rokkedal, J., & Ibsen, H. (2005). Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy. Journal of Human Hypertension, 19(4), 301-7. https://doi.org/10.1038/sj.jhh.1001819

Olsen, MH, Christensen, MK, Wachtell, K, Tuxen, C, Fossum, E, Bang, LE , Wiinberg, N, Devereux, RB, Kjeldsen, SE, Hildebrandt, P, Dige-Petersen, H, Rokkedal, J & Ibsen, H 2005, 'Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy', Journal of Human Hypertension, bind 19, nr. 4, s. 301-7. https://doi.org/10.1038/sj.jhh.1001819

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title = "Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy",

abstract = "Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P",

keywords = "Aged, Antihypertensive Agents, Biological Markers, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Carotid Artery, Common, Collagen, Collagen Type I, Electrocardiography, Female, Follow-Up Studies, Humans, Hypertension, Hypertrophy, Hypertrophy, Left Ventricular, Male, Peptide Fragments, Peptides, Plethysmography, Procollagen, Radioimmunoassay, Vascular Resistance",

author = "Olsen, {M H} and Christensen, {M K} and K Wachtell and Christian Tuxen and E Fossum and Bang, {L E} and N Wiinberg and Devereux, {R B} and Kjeldsen, {S E} and Per Hildebrandt and H Dige-Petersen and J Rokkedal and H Ibsen",

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doi = "10.1038/sj.jhh.1001819",

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T1 - Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

AU - Olsen, M H

AU - Christensen, M K

AU - Wachtell, K

AU - Tuxen, Christian

AU - Fossum, E

AU - Bang, L E

AU - Wiinberg, N

AU - Devereux, R B

AU - Kjeldsen, S E

AU - Hildebrandt, Per

AU - Dige-Petersen, H

AU - Rokkedal, J

AU - Ibsen, H

PY - 2005

Y1 - 2005

N2 - Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P

AB - Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P

KW - Aged

KW - Antihypertensive Agents

KW - Biological Markers

KW - Blood Pressure

KW - Blood Pressure Monitoring, Ambulatory

KW - Carotid Artery, Common

KW - Collagen

KW - Collagen Type I

KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hypertension

KW - Hypertrophy

KW - Hypertrophy, Left Ventricular

KW - Male

KW - Peptide Fragments

KW - Peptides

KW - Plethysmography

KW - Procollagen

KW - Radioimmunoassay

KW - Vascular Resistance

U2 - 10.1038/sj.jhh.1001819

DO - 10.1038/sj.jhh.1001819

M3 - Journal article

C2 - 15647776

VL - 19

SP - 301

EP - 307

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 4

ER -

Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

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