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Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig

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Harvard

Lind, NM, Alstrup, AKO, Moustgaard, AC, Jensen, SB, Jakobsen, S, Hansen, AK, Arnfred, SM, Hemmingsen, RP, Gjedde, A & Cumming, P 2005, 'Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig', Brain Research Bulletin, bind 65, nr. 1, s. 1-9. https://doi.org/10.1016/j.brainresbull.2004.08.007

APA

Lind, N. M., Alstrup, A. K. O., Moustgaard, A. C., Jensen, S. B., Jakobsen, S., Hansen, A. K., Arnfred, S. M., Hemmingsen, R. P., Gjedde, A., & Cumming, P. (2005). Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig. Brain Research Bulletin, 65(1), 1-9. https://doi.org/10.1016/j.brainresbull.2004.08.007

CBE

Lind NM, Alstrup AKO, Moustgaard AC, Jensen SB, Jakobsen S, Hansen AK, Arnfred SM, Hemmingsen RP, Gjedde A, Cumming P. 2005. Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig. Brain Research Bulletin. 65(1):1-9. https://doi.org/10.1016/j.brainresbull.2004.08.007

MLA

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Author

Lind, Nanna Marie ; Alstrup, Aage Kristian Olsen ; Moustgaard, Anette Caroline ; Jensen, Svend Borup ; Jakobsen, Steen ; Hansen, Axel Kornerup ; Arnfred, Sidse Marie ; Hemmingsen, Ralf Peter ; Gjedde, Albert ; Cumming, Paul. / Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig. I: Brain Research Bulletin. 2005 ; Bind 65, Nr. 1. s. 1-9.

Bibtex

@article{5a4cfd12ccfc4763a9b28ca531d8291d,
title = "Mapping the amphetamine-evoked dopamine release in the brain of the G{\"o}ttingen minipig",
abstract = "The availability of dopamine D(2/3) binding sites in brain of six male and six female G{\"o}ttingen minipigs was measured in a baseline condition and after challenge with amphetamine sulfate (1mg/kg, i.v.) in PET studies with [(11)C]raclopride. Maps of the binding potential (pB; B(max)/K(d)) of [(11)C]raclopride were spatially normalized and co-registered to a common stereotaxic coordinate system for pig brain. The pB maps were then analyzed by volume of interest and voxel-wise comparisons of gender and condition. The mean baseline pB tended to be 10-20% higher in striatum of the female group, but this gender difference was not significant. Variance of the mean baseline pB was higher in the males (44%) than in females (30%), but there was no correlation between pB and individual plasma cortisol or testosterone concentrations. Using statistical parametric mapping, we detected a focus in the right posterior putamen where the magnitude of the amphetamine-evoked decrease in pB was greater in the male than in the female group. Thus, the spatial pattern of reactivity of dopamine D(2/3) receptor availability to amphetamine challenge is not identical in male and female pigs. Within the entire population, the decline in pB evoked by amphetamine (Delta pB) was greater in the ventral striatum (-28%) than in the caudate nucleus (-17%), consistent with earlier reports in monkeys and humans. The magnitude of Delta pB correlated highly with the baseline pB values in all divisions of the striatum. Based upon the principles of competitive binding, the slope of this empirical relationship, f(i), is equal to the fraction of [(11)C]raclopride binding sites sensitive to endogenous dopamine; the magnitude of this fraction ranged from 0.29 in the caudate to 0.36 in the ventral striatum.",
keywords = "Amphetamine, Analysis of Variance, Animals, Binding, Competitive, Brain, Brain Chemistry, Brain Mapping, Carbon Isotopes, Central Nervous System Stimulants, Dopamine, Female, Male, Positron-Emission Tomography, Raclopride, Sex Factors, Swine, Swine, Miniature",
author = "Lind, {Nanna Marie} and Alstrup, {Aage Kristian Olsen} and Moustgaard, {Anette Caroline} and Jensen, {Svend Borup} and Steen Jakobsen and Hansen, {Axel Kornerup} and Arnfred, {Sidse Marie} and Hemmingsen, {Ralf Peter} and Albert Gjedde and Paul Cumming",
year = "2005",
month = feb,
day = "15",
doi = "10.1016/j.brainresbull.2004.08.007",
language = "English",
volume = "65",
pages = "1--9",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc",
number = "1",

}

RIS

TY - JOUR

T1 - Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig

AU - Lind, Nanna Marie

AU - Alstrup, Aage Kristian Olsen

AU - Moustgaard, Anette Caroline

AU - Jensen, Svend Borup

AU - Jakobsen, Steen

AU - Hansen, Axel Kornerup

AU - Arnfred, Sidse Marie

AU - Hemmingsen, Ralf Peter

AU - Gjedde, Albert

AU - Cumming, Paul

PY - 2005/2/15

Y1 - 2005/2/15

N2 - The availability of dopamine D(2/3) binding sites in brain of six male and six female Göttingen minipigs was measured in a baseline condition and after challenge with amphetamine sulfate (1mg/kg, i.v.) in PET studies with [(11)C]raclopride. Maps of the binding potential (pB; B(max)/K(d)) of [(11)C]raclopride were spatially normalized and co-registered to a common stereotaxic coordinate system for pig brain. The pB maps were then analyzed by volume of interest and voxel-wise comparisons of gender and condition. The mean baseline pB tended to be 10-20% higher in striatum of the female group, but this gender difference was not significant. Variance of the mean baseline pB was higher in the males (44%) than in females (30%), but there was no correlation between pB and individual plasma cortisol or testosterone concentrations. Using statistical parametric mapping, we detected a focus in the right posterior putamen where the magnitude of the amphetamine-evoked decrease in pB was greater in the male than in the female group. Thus, the spatial pattern of reactivity of dopamine D(2/3) receptor availability to amphetamine challenge is not identical in male and female pigs. Within the entire population, the decline in pB evoked by amphetamine (Delta pB) was greater in the ventral striatum (-28%) than in the caudate nucleus (-17%), consistent with earlier reports in monkeys and humans. The magnitude of Delta pB correlated highly with the baseline pB values in all divisions of the striatum. Based upon the principles of competitive binding, the slope of this empirical relationship, f(i), is equal to the fraction of [(11)C]raclopride binding sites sensitive to endogenous dopamine; the magnitude of this fraction ranged from 0.29 in the caudate to 0.36 in the ventral striatum.

AB - The availability of dopamine D(2/3) binding sites in brain of six male and six female Göttingen minipigs was measured in a baseline condition and after challenge with amphetamine sulfate (1mg/kg, i.v.) in PET studies with [(11)C]raclopride. Maps of the binding potential (pB; B(max)/K(d)) of [(11)C]raclopride were spatially normalized and co-registered to a common stereotaxic coordinate system for pig brain. The pB maps were then analyzed by volume of interest and voxel-wise comparisons of gender and condition. The mean baseline pB tended to be 10-20% higher in striatum of the female group, but this gender difference was not significant. Variance of the mean baseline pB was higher in the males (44%) than in females (30%), but there was no correlation between pB and individual plasma cortisol or testosterone concentrations. Using statistical parametric mapping, we detected a focus in the right posterior putamen where the magnitude of the amphetamine-evoked decrease in pB was greater in the male than in the female group. Thus, the spatial pattern of reactivity of dopamine D(2/3) receptor availability to amphetamine challenge is not identical in male and female pigs. Within the entire population, the decline in pB evoked by amphetamine (Delta pB) was greater in the ventral striatum (-28%) than in the caudate nucleus (-17%), consistent with earlier reports in monkeys and humans. The magnitude of Delta pB correlated highly with the baseline pB values in all divisions of the striatum. Based upon the principles of competitive binding, the slope of this empirical relationship, f(i), is equal to the fraction of [(11)C]raclopride binding sites sensitive to endogenous dopamine; the magnitude of this fraction ranged from 0.29 in the caudate to 0.36 in the ventral striatum.

KW - Amphetamine

KW - Analysis of Variance

KW - Animals

KW - Binding, Competitive

KW - Brain

KW - Brain Chemistry

KW - Brain Mapping

KW - Carbon Isotopes

KW - Central Nervous System Stimulants

KW - Dopamine

KW - Female

KW - Male

KW - Positron-Emission Tomography

KW - Raclopride

KW - Sex Factors

KW - Swine

KW - Swine, Miniature

U2 - 10.1016/j.brainresbull.2004.08.007

DO - 10.1016/j.brainresbull.2004.08.007

M3 - Journal article

C2 - 15680539

VL - 65

SP - 1

EP - 9

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 1

ER -

ID: 32752606