Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus

Tommy Øhlenschlaeger; Peter Garred; Hans O Madsen; Søren Jacobsen

doi:10.1056/NEJMoa033122

Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus

Tommy Øhlenschlaeger
, Peter Garred
, Hans O Madsen
, Søren Jacobsen

Afdeling for Klinisk Immunologi

198 Citationer (Scopus)

Abstract

Cardiovascular disease is an important complication in patients with systemic lupus erythematosus (SLE). Variant alleles of the mannose-binding lectin gene are associated with SLE as well as with severe atherosclerosis. We determined whether mannose-binding lectin variant alleles were associated with an increased risk of arterial thrombosis among patients with SLE.

Originalsprog	Engelsk
Tidsskrift	The New England journal of medicine
Vol/bind	351
Udgave nummer	3
Sider (fra-til)	260-7
Antal sider	8
ISSN	0028-4793
DOI	https://doi.org/10.1056/NEJMoa033122
Status	Udgivet - 15 jul. 2004

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10.1056/NEJMoa033122

Citationsformater

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title = "Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus",

abstract = "Cardiovascular disease is an important complication in patients with systemic lupus erythematosus (SLE). Variant alleles of the mannose-binding lectin gene are associated with SLE as well as with severe atherosclerosis. We determined whether mannose-binding lectin variant alleles were associated with an increased risk of arterial thrombosis among patients with SLE.",

keywords = "Adolescent, Adult, Aged, Alleles, Antibodies, Anticardiolipin, Female, Genotype, Humans, Incidence, Lupus Erythematosus, Systemic, Male, Mannose-Binding Lectin, Middle Aged, Polymerase Chain Reaction, Polymorphism, Genetic, Prospective Studies, Risk Factors, Thrombosis",

author = "Tommy {\O}hlenschlaeger and Peter Garred and Madsen, \{Hans O\} and S{\o}ren Jacobsen",

year = "2004",

month = jul,

day = "15",

doi = "10.1056/NEJMoa033122",

language = "English",

volume = "351",

pages = "260--7",

journal = "The New England journal of medicine",

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TY - JOUR

T1 - Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus

AU - Øhlenschlaeger, Tommy

AU - Garred, Peter

AU - Madsen, Hans O

AU - Jacobsen, Søren

PY - 2004/7/15

Y1 - 2004/7/15

N2 - Cardiovascular disease is an important complication in patients with systemic lupus erythematosus (SLE). Variant alleles of the mannose-binding lectin gene are associated with SLE as well as with severe atherosclerosis. We determined whether mannose-binding lectin variant alleles were associated with an increased risk of arterial thrombosis among patients with SLE.

AB - Cardiovascular disease is an important complication in patients with systemic lupus erythematosus (SLE). Variant alleles of the mannose-binding lectin gene are associated with SLE as well as with severe atherosclerosis. We determined whether mannose-binding lectin variant alleles were associated with an increased risk of arterial thrombosis among patients with SLE.

KW - Adolescent

KW - Adult

KW - Aged

KW - Alleles

KW - Antibodies, Anticardiolipin

KW - Female

KW - Genotype

KW - Humans

KW - Incidence

KW - Lupus Erythematosus, Systemic

KW - Male

KW - Mannose-Binding Lectin

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Polymorphism, Genetic

KW - Prospective Studies

KW - Risk Factors

KW - Thrombosis

U2 - 10.1056/NEJMoa033122

DO - 10.1056/NEJMoa033122

M3 - Journal article

C2 - 15254284

SN - 0028-4793

VL - 351

SP - 260

EP - 267

JO - The New England journal of medicine

JF - The New England journal of medicine

IS - 3

ER -

Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus

Abstract

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