Mannanbindende lektin og mortalitet hos patienter med type 2-diabetes--sekundaerpublikation

Troels Krarup Hansen; Mari-Anne Gall; Lise Tarnow; Steffen Thiel

Mannanbindende lektin og mortalitet hos patienter med type 2-diabetes--sekundaerpublikation

Troels Krarup Hansen, Mari-Anne Gall, Lise Tarnow, Steffen Thiel

3 Citationer (Scopus)

Abstrakt

We evaluated the relationship between serum mannose-binding lectin (MBL) and mortality and incident albuminuria in 326 patients with type 2 diabetes mellitus (T2DM). During 15 years of follow-up, 169 patients died. In a multivariate analysis, MBL was a significant risk factor for death from any cause and added to the predictive power of CRP. Normoalbuminuric patients with both high MBL and high C-reactive protein (CRP) levels had a significantly increased risk of developing albuminuria. We conclude that MBL alone or in combination with CRP can provide prognostic information on mortality and the development of albuminuria in T2DM

Bidragets oversatte titel	Mannose-binding lectin and mortality in patients with type 2 diabetes mellitus--secondary publication
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	171
Udgave nummer	6
Sider (fra-til)	426-9
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 2 feb. 2009
Udgivet eksternt	Ja

Emneord

Albuminuria
C-Reactive Protein
Cohort Studies
Diabetes Mellitus, Type 2
Female
Follow-Up Studies
Humans
Male
Mannose-Binding Lectin
Middle Aged
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Factors

Citationsformater

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title = "Mannanbindende lektin og mortalitet hos patienter med type 2-diabetes--sekundaerpublikation",

abstract = "We evaluated the relationship between serum mannose-binding lectin (MBL) and mortality and incident albuminuria in 326 patients with type 2 diabetes mellitus (T2DM). During 15 years of follow-up, 169 patients died. In a multivariate analysis, MBL was a significant risk factor for death from any cause and added to the predictive power of CRP. Normoalbuminuric patients with both high MBL and high C-reactive protein (CRP) levels had a significantly increased risk of developing albuminuria. We conclude that MBL alone or in combination with CRP can provide prognostic information on mortality and the development of albuminuria in T2DM",

keywords = "Albuminuria, C-Reactive Protein, Cohort Studies, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Male, Mannose-Binding Lectin, Middle Aged, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Factors, English Abstract, Journal Article",

author = "Hansen, {Troels Krarup} and Mari-Anne Gall and Lise Tarnow and Steffen Thiel",

year = "2009",

month = feb,

day = "2",

language = "Dansk",

volume = "171",

pages = "426--9",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "6",

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TY - JOUR

T1 - Mannanbindende lektin og mortalitet hos patienter med type 2-diabetes--sekundaerpublikation

AU - Hansen, Troels Krarup

AU - Gall, Mari-Anne

AU - Tarnow, Lise

AU - Thiel, Steffen

PY - 2009/2/2

Y1 - 2009/2/2

N2 - We evaluated the relationship between serum mannose-binding lectin (MBL) and mortality and incident albuminuria in 326 patients with type 2 diabetes mellitus (T2DM). During 15 years of follow-up, 169 patients died. In a multivariate analysis, MBL was a significant risk factor for death from any cause and added to the predictive power of CRP. Normoalbuminuric patients with both high MBL and high C-reactive protein (CRP) levels had a significantly increased risk of developing albuminuria. We conclude that MBL alone or in combination with CRP can provide prognostic information on mortality and the development of albuminuria in T2DM

AB - We evaluated the relationship between serum mannose-binding lectin (MBL) and mortality and incident albuminuria in 326 patients with type 2 diabetes mellitus (T2DM). During 15 years of follow-up, 169 patients died. In a multivariate analysis, MBL was a significant risk factor for death from any cause and added to the predictive power of CRP. Normoalbuminuric patients with both high MBL and high C-reactive protein (CRP) levels had a significantly increased risk of developing albuminuria. We conclude that MBL alone or in combination with CRP can provide prognostic information on mortality and the development of albuminuria in T2DM

KW - Albuminuria

KW - C-Reactive Protein

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Mannose-Binding Lectin

KW - Middle Aged

KW - Prognosis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - English Abstract

KW - Journal Article

M3 - Tidsskriftartikel

C2 - 19213151

VL - 171

SP - 426

EP - 429

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 6

ER -

Mannanbindende lektin og mortalitet hos patienter med type 2-diabetes--sekundaerpublikation

Abstrakt

Emneord

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Citationsformater