TY - JOUR
T1 - Management of Post-transplant Infections in Collaborating Hospitals (MATCH) Programme
T2 - a prospective cohort of all transplant recipients at Copenhagen University Hospital-Rigshospitalet, Denmark
AU - Esmann, Frederik Viggo Lautrup
AU - Zahid, Sadaf
AU - Moestrup, Kasper Sommerlund
AU - Normand, Nick
AU - Matthews, Charlotte
AU - Gustafsson, Finn
AU - Sengeløv, Henrik
AU - Perch, Michael
AU - Schultz, Nicolai Aagaard
AU - Sørensen, Søren Schwartz
AU - Hansen, Jesper Melchior
AU - Christensen, Vibeke Brix
AU - Murray, Daniel D
AU - Lundgren, J
AU - Crone, Cornelia Geisler
AU - Helleberg, Marie
N1 - © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2024/11/13
Y1 - 2024/11/13
N2 - PURPOSE: The Management of Post-transplant Infections in Collaborating Hospitals (MATCH) programme, initiated in 2011 and still ongoing, was created to 1) optimise the implementation of existing preventive strategies against viral infections in solid organ transplant (SOT) recipients and allogenic haematopoietic stem-cell transplant (HSCT) recipients and 2) advance research in the field of transplantation by collecting data from a multitude of sources.PARTICIPANTS: All SOT and HSCT recipients at Copenhagen University Hospital, Rigshospitalet, are followed in MATCH. By February 2021, a total of 1192 HSCT recipients and 2039 SOT recipients have been included. Participants are followed life long. An automated electronic data capture system retrieves prospective data from nationwide registries. Data from the years prior to transplantation are also collected.FINDINGS TO DATE: Data entries before and after transplantation include the following: biochemistry: 13 995 222 and 26 127 817; microbiology, cultures: 242 023 and 410 558; other microbiological analyses: 265 007 and 566 402; and pathology: 170 884 and 200 394. There are genomic data on 2431 transplant recipients, whole blood biobank samples from 1003 transplant recipients and faeces biobank samples from 207 HSCT recipients. Clinical data collected in MATCH have contributed to 50 scientific papers published in peer-reviewed journals and have demonstrated success in reducing cytomegalovirus disease in SOT recipients. The programme has established international collaborations with the Swiss Transplant Cohort Study and the lung transplant cohort at Toronto General Hospital.FUTURE PLANS: Enrolment into MATCH is ongoing with no planned end date for enrolment or follow-up. MATCH will continue to provide high-quality data on transplant recipients and expand and strengthen international collaborations.
AB - PURPOSE: The Management of Post-transplant Infections in Collaborating Hospitals (MATCH) programme, initiated in 2011 and still ongoing, was created to 1) optimise the implementation of existing preventive strategies against viral infections in solid organ transplant (SOT) recipients and allogenic haematopoietic stem-cell transplant (HSCT) recipients and 2) advance research in the field of transplantation by collecting data from a multitude of sources.PARTICIPANTS: All SOT and HSCT recipients at Copenhagen University Hospital, Rigshospitalet, are followed in MATCH. By February 2021, a total of 1192 HSCT recipients and 2039 SOT recipients have been included. Participants are followed life long. An automated electronic data capture system retrieves prospective data from nationwide registries. Data from the years prior to transplantation are also collected.FINDINGS TO DATE: Data entries before and after transplantation include the following: biochemistry: 13 995 222 and 26 127 817; microbiology, cultures: 242 023 and 410 558; other microbiological analyses: 265 007 and 566 402; and pathology: 170 884 and 200 394. There are genomic data on 2431 transplant recipients, whole blood biobank samples from 1003 transplant recipients and faeces biobank samples from 207 HSCT recipients. Clinical data collected in MATCH have contributed to 50 scientific papers published in peer-reviewed journals and have demonstrated success in reducing cytomegalovirus disease in SOT recipients. The programme has established international collaborations with the Swiss Transplant Cohort Study and the lung transplant cohort at Toronto General Hospital.FUTURE PLANS: Enrolment into MATCH is ongoing with no planned end date for enrolment or follow-up. MATCH will continue to provide high-quality data on transplant recipients and expand and strengthen international collaborations.
KW - Humans
KW - Denmark
KW - Prospective Studies
KW - Hematopoietic Stem Cell Transplantation
KW - Female
KW - Male
KW - Adult
KW - Transplant Recipients/statistics & numerical data
KW - Middle Aged
KW - Organ Transplantation/adverse effects
KW - Registries
KW - Hospitals, University
KW - Adolescent
KW - Young Adult
KW - Virus Diseases/prevention & control
KW - Aged
KW - Child
KW - Postoperative Complications/prevention & control
UR - http://www.scopus.com/inward/record.url?scp=85209395600&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2024-089966
DO - 10.1136/bmjopen-2024-089966
M3 - Journal article
C2 - 39537569
SN - 2044-6055
VL - 14
SP - e089966
JO - BMJ Open
JF - BMJ Open
IS - 11
ER -